Selected Publications
2012
Photochemical Restoration of Visual Responses in Blind Mice
Neuron, Volume 75, Issue 2, 271-282, 2012
Rab3a Mediates Vesicle Delivery at Photoreceptor Ribbon Synapses
Tian, M.; Xu, C.S.; Montpetit, R.; Kramer, R.H.
Journal of Neuroscience, Volume 32, Issue 20, 6931-6, 2012
Rapid optical control of nociception with an ion-channel photoswitch
Mourot, A.; Fehrentz, T.; Le Feuvre, Y.; Smith, C.; Herold, C.; Dalkara, D.; Nagy, F.; Trauner, D. & Kramer R.H.
Nature Methods, 9, 396-402, 2012
Optochemical control of genetically engineered neuronal nicotinic acetylcholine receptors
Tochitsky, I.; Banghart, M.R.; Mourot, A.; Yao, J.Z.; Gaub, B.; Kramer, R.H.; & Trauner,D.
Nature Chemistry, 4, 105–111, 2012
2011
A positive feedback synapse from retinal horizontal cells to cone photoreceptors
Jackman, S.L., Babai, N., Chambers, J.J., Thoreson, W.B. & Kramer, R.H.
PLoS Biol , Vol. 9(5), e1001057, 2011
Optogenetic photochemical control of designer K+ channels in mammalian neurons
Fortin, D.L., Dunn, T.W., Fedorchak, A., Allen, D., Montpetit, R., Banghart, M.R., Trauner, D., Adelman, J.P. & Kramer, R.H.
J Neurophysiol, Vol. 106(1), pp. 488-496, 2011
Engineering light-regulated ion channels
Fortin, D.L., Dunn, T.W. & Kramer, R.H.
Cold Spring Harb Protoc, Vol. 2011(6),579-585, 2011
Release from the cone ribbon synapse under bright light conditions can be controlled by the opening of only a few Ca2+ channels
Bartoletti, T.M., Jackman, S.L., Babai, N., Mercer, A.J., Kramer, R.H. & Thoreson, W.B.
J Neurophysiol 106, 2922-2935, 2011
2009
New photochemical tools for controlling neuronal activity
Kramer, R.H., Fortin, D.L. & Trauner, D.
Curr Opin Neurobiol, Vol. 19(5), 544-552, 2009
Role of the synaptic ribbon in transmitting the cone light response
Jackman, S.L., Choi, S.-Y., Thoreson, W.B., Rabl, K., Bartoletti, T.M. & Kramer, R.H.Nat Neurosci, Vol. 12(3), 303-310, 2009
Photochromic blockers of voltage-gated potassium channels
Banghart, M.R., Mourot, A., Fortin, D.L., Yao, J.Z., Kramer, R.H. & Trauner, D.
Angew Chem Int Ed Engl , Vol. 48(48), 9097-9101, 2009
2008
Light-activated ion channels for remote control of neural activity
Chambers, J.J. & Kramer, R.H.
Methods Cell Biol, Vol. 90, 217-232, 2008
Photochemical control of endogenous ion channels and cellular excitability
Fortin, D.L., Banghart, M.R., Dunn, T.W., Borges, K., Wagenaar, D.A., Gaudry, Q., Karakossian, M.H., Otis, T.S., Kristan, W.B., Trauner, D. & Kramer, R.H.
Nat Methods, Vol. 5(4), 331-338, 2008
Light regulation of Ca2+ in the cone photoreceptor synaptic terminal
Choi, S.-Y., Jackman, S., Thoreson, W.B. & Kramer, R.H.
Vis Neurosci, Vol. 25(5-6), 693-700, 2008
2007
Synaptic Ca2+ in darkness is lower in rods than cones, causing slower tonic release of vesicles
Sheng, Z., Choi, S.-Y., Dharia, A., Li, J., Sterling, P. & Kramer, R.H.
J Neurosci, Vol. 27(19), 5033-5042,2007
Remote control of neuronal activity with a light-gated glutamate receptor
Szobota, S., Gorostiza, P., Bene, F.D., Wyart, C., Fortin, D.L., Kolstad, K.D., Tulyathan, O., Volgraf, M., Numano, R., Aaron, H.L., Scott, E.K., Kramer, R.H., Flannery, J., Baier, H., Trauner, D. & Isacoff, E.Y.
Neuron , Vol. 54(4), 535-545, 2007
Staples, tape measures, and bungee cords: a variety of bifunctional reagents for understanding and controlling ion channels
Mourot, A. & Kramer, R.H.
ACS Chem Biol, Vol. 2(7), 451-453, 2007
2006
Allosteric control of an ionotropic glutamate receptor with an optical switch
Volgraf, M., Gorostiza, P., Numano, R., Kramer, R.H., Isacoff, E.Y. & Trauner, D.
Nat Chem Biol, Vol. 2(1), 47-52, 2006
Light-induced depolarization of neurons using a modified Shaker K(+) channel and a molecular photoswitch
Chambers, J.J., Banghart, M.R., Trauner, D. & Kramer, R.H.
J Neurophysiol, Vol. 96(5), 2792-2796, 2006
2005
Photochemical tools for remote control of ion channels in excitable cells
Kramer, R.H., Chambers, J.J. & Trauner, D.
Nat Chem Biol, Vol. 1(7), 360-365, 2005
Encoding light intensity by the cone photoreceptor synapse
Choi, S.-Y., Borghuis, B.G., Borghuis, B., Rea, R., Levitan, E.S., Sterling, P. & Kramer, R.H.
Neuron, Vol. 48(4), 555-562, 2005
Imaging light-modulated release of synaptic vesicles in the intact retina: retinal physiology at the dawn of the post-electrode era
Choi, S.-Y., Sheng, Z. & Kramer, R.H.
Vision Res, Vol. 45(28), 3487-3495, 2005
Flashy science: controlling neural function with light
Thompson, S.M., Kao, J.P.Y., Kramer, R.H., Poskanzer, K.E., Silver, R.A., Digregorio, D. & Wang, S.S.-H.
J Neurosci, Vol. 25(45), 10358-10365, 2005
2004
Metabolic modulation of potassium channels
Trauner, D. & Kramer, R.H.
Sci STKE, Vol. 2004(233), pe22, 2004
Streamlined synaptic vesicle cycle in cone photoreceptor terminals
Rea, R., Li, J., Dharia, A., Levitan, E.S., Sterling, P. & Kramer, R.H.
Neuron, Vol. 41(5), 755-766,2004
Light-activated ion channels for remote control of neuronal firing
Banghart, M., Borges, K., Isacoff, E., Trauner, D. & Kramer, R.H.
Nat Neurosci, Vol. 7(12), 1381-1386, 2004