Publications

2011
1. Gao Q, Steine E, Barrasa M, Hockemeyer D, Pawlak M, Fu D, Reddy S, Bell G, Jaenisch R. (2011) Deletion of the de novo methyltransferase Dnmt3a promotes lung tumor progression. Proceedings of the National Academy of Sciences of the United States of America (in press) [PDF][PubMed]
2. Major T, Menon J, Auyeung G, Soldner F, Hockemeyer D, Jaenisch R, Tabar V. (2011) Transgene Excision Has No Impact on In Vivo Integration of Human iPS Derived Neural Precursors. PLoS ONE 6: e24687 [PDF][PubMed
3. Soldner F, Laganiere J, Cheng AW, Hockemeyer D, Gao Q, Alagappan R, Khurana V, Golbe LI, Myers RH, Lindquist S, Zhang L, Guschin D, Fong LK, Vu BJ, Meng X, Urnov FD, Rebar EJ, Gregory PD, Zhang HS, Jaenisch R. (2011) Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell 146: 318-31 [PDF][PubMed]
4. Hockemeyer D*, Wang H*, Kiani S, Lai CS, Gao Q, Cassady JP, Cost GJ, Zhang L, Santiago Y, Miller JC, Zeitler B, Cherone JM, Meng X, Hinkley SJ, Rebar EJ, Gregory PD, Urnov FD, Jaenisch R. (2011) Genetic engineering of human pluripotent cells using TALE nucleases. Nature biotechnology 29: 731-4 *equal contribution [PDF][PubMed]

2010
5. Hockemeyer D, Jaenisch R. (2010) Gene targeting in human pluripotent cells. Cold Spring Harbor symposia on quantitative biology 75: 201-9 [PDF][PubMed]
6. Hargus G, Cooper O, Deleidi M, Levy A, Lee K, Marlow E, Yow A, Soldner F, Hockemeyer D, Hallett PJ, Osborn T, Jaenisch R, Isacson O. (2010) Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats. Proceedings of the National Academy of Sciences of the United States of America 107: 15921-6 [PDF][PubMed]
7. Guenther MG, Frampton GM, Soldner F, Hockemeyer D, Mitalipova M, Jaenisch R, Young RA. (2010) Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. Cell Stem Cell 7: 249-57 [PDF][PubMed]
8. DeKelver RC, Choi VM, Moehle EA, Paschon DE, Hockemeyer D, Meijsing SH, Sancak Y, Cui X, Steine EJ, Miller JC, Tam P, Bartsevich VV, Meng X, Rupniewski I, Gopalan SM, Sun HC, Pitz KJ, Rock JM, Zhang L, Davis GD, Rebar EJ, Cheeseman IM, Yamamoto KR, Sabatini DM, Jaenisch R, Gregory PD, Urnov FD. (2010) Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Research 20: 1133-42 [PDF][PubMed] 

2009
9. Soldner F*, Hockemeyer D*, Beard C, Gao Q, Bell GW, Cook EG, Hargus G, Blak A, Cooper O, Mitalipova M, Isacson O, Jaenisch R. (2009) Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell 136: 964-77 *equal contribution [PDF][PubMed
10. Sfeir A, Kosiyatrakul ST, Hockemeyer D, MacRae SL, Karlseder J, Schildkraut CL, de Lange T. (2009) Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell 138: 90-103 [PDF][PubMed]
11. Palm W, Hockemeyer D, Kibe T, de Lange T. (2009) Functional dissection of human and mouse POT1 proteins. Molecular and Cellular Biology 29: 471-82 [PDF]           [PubMed]
12. Hockemeyer D*, Soldner F*, Beard C, Gao Q, Mitalipova M, DeKelver RC, Katibah GE, Amora R, Boydston EA, Zeitler B, Meng X, Miller JC, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Jaenisch R. (2009) Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nature Biotechnology 27: 851-7 *equal contribution [PDF][PubMed]
13. Hockemeyer D, Soldner, F., Jaenisch, R. (2009) Direct reprogramming of somatic cells to a pluripotent state. In In Essentials of Stem Cell Biology, Second edition, pp. pp. 29-32. (San Diego, USA, Academic Press, Elsevier): Robert Lanza, John Gearhart, Brigid Hogan, Douglas Melton, Roger Pederson, E. Donnall Thomas, James Thomson, and Sir Ian Wilmut [PDF]

2002-2008
14. Hockemeyer D*, Soldner F*, Cook EG, Gao Q, Mitalipova M, Jaenisch R. (2008) A drug-inducible system for direct reprogramming of human somatic cells to pluripotency. Cell Stem Cell 3: 346-53 *equal contribution [PDF][PubMed]
15. Hockemeyer D, Palm W, Wang RC, Couto SS, de Lange T. (2008) Engineered telomere degradation models dyskeratosis congenita. Genes & Development 22: 1773-85 [PDF][PubMed]
16. Hockemeyer D, Palm W, Else T, Daniels JP, Takai KK, Ye JZ, Keegan CE, de Lange T, Hammer GD. (2007) Telomere protection by mammalian Pot1 requires interaction with Tpp1. Nature Structural & Molecular Biology 14: 754-61[PDF][PubMed]
17. Hockemeyer D, Daniels JP, Takai H, de Lange T. (2006) Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres. Cell 126: 63-77 [PDF][PubMed]
18. Hockemeyer D, Sfeir AJ, Shay JW, Wright WE, de Lange T. (2005) POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. The EMBO journal 24: 2667-78 [PDF][PubMed]
19. Ye JZ, Hockemeyer D, Krutchinsky AN, Loayza D, Hooper SM, Chait BT, de Lange T. (2004) POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes & Development 18: 1649-54 [PDF][PubMed]
20. Wang Z, Wang DZ, Hockemeyer D, McAnally J, Nordheim A, Olson EN. (2004) Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression. Nature 428: 185-9 [PDF][PubMed]
21. Schratt G, Philippar U, Hockemeyer D, Schwarz H, Alberti S, Nordheim A. (2004) SRF regulates Bcl-2 expression and promotes cell survival during murine embryonic development. The EMBO Journal 23: 1834-44 [PDF][PubMed]
22. Wang DZ, Li S, Hockemeyer D, Sutherland L, Wang Z, Schratt G, Richardson JA, Nordheim A, Olson EN. (2002) Potentiation of serum response factor activity by a family of myocardin-related transcription factors. Proceedings of the National Academy of Sciences of the United States of America 99: 14855-60 [PDF][PubMed]
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