Investigating the Repetitive Telomeric DNA Sequence: (TTAGGG)n
Tissue Culture Based Model System: Human Pluripotent Stem Cells
Mechanisms of Telomerase Regulation upon Differentiation and Tumor Formation
Recent Lab News
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Congratulations to Chiba, Josh, Tina and John on the publication of "Cancer-associated TERT promoter mutations abrogate telomerase silencing" in eLIFE!
The July issue of eLIFE also features this paper with an Insight on this paper written by Dr. Kamila Naxerova and Dr. Stephen Elledge!
UC Berkeley sophomore in Molecular and Cell Biology, Shannon Wu, joins the lab!
University of Michigan junior in Cellular and Molecular Biology, Rebecca Bartke, joins the lab for the summer as a part of the Amgen Scholars Program!
Congratulations to Tiffany on completing her B.Sc. degree in Chemical Biology!
Link to lab publications
Title: Cancer-associated TERT promoter mutations abrogate telomerase silencing
Lab members involved: Kunitoshi Chiba, Joshua Johnson, Tina Wagner, John Boyle, Dirk Hockemeyer
Title: Genome editing in human pluripotent stem cells using site-specific nucleases
Lab members involved: Kunitoshi Chiba, Dirk Hockemeyer
Link to research background
Questions to address in regards to telomere maintenance and mechanisms governing telomerase regulation in human pluripotent stem cells:
1) What is the mechanism of telomerase regulation in human stem cells, upon their differentiation and during tumor formation?
2) What are the molecular mechanisms underlying the recruitment of telomerase to the telomere in human cells?
3) What are the consequences of telomere shortening in stem cells and how does this impact tumor formation?
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