Investigating the Repetitive Telomeric DNA Sequence: (TTAGGG)n
Tissue Culture Based Model System: Human Pluripotent Stem Cells
Mechanisms of Telomerase Regulation upon Differentiation and Tumor Formation
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UC Berkeley junior in Molecular and Cell Biology, Erica Keane, joins the lab!
UC Berkeley freshman in Bioengineering, Justin Lu, joins the lab!
Lab Photo Day!
Congratulations to Sam and Josh on the publication of "Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies" in eLife!
Link to lab publications
Title: Endogenous TERT N-terminal tagging affects human telomerase function at telomeres in vivo.
Lab members involved: Kunitoshi Chiba, Manraj Gill
Title: Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies.
Lab members involved: Samuel Regalado, Joshua Johnson
Link to research background
Questions to address in regards to telomere maintenance and mechanisms governing telomerase regulation in human pluripotent stem cells:
1) What is the mechanism of telomerase regulation in human stem cells, upon their differentiation and during tumor formation?
2) What are the molecular mechanisms underlying the recruitment of telomerase to the telomere in human cells?
3) What are the consequences of telomere shortening in stem cells and how does this impact tumor formation?
The Pew Charitable Trusts:
Pew-Stewart Program for Cancer Research
National Institutes of Health
"The Ellison Medical Foundation supports basic biomedical research on aging relevant to understanding lifespan development processes and age-related diseases and disabilities."
"The purpose of the Glenn Foundation for Medical Research, founded in 1965 by Paul F. Glenn, is to extend the healthy productive years of life through research on the mechanisms of biological aging."
Shurl and Kay Curci Foundation
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