Investigating the Repetitive Telomeric DNA Sequence: (TTAGGG)n
Tissue Culture Based Model System: Human Pluripotent Stem Cells
Mechanisms of Telomerase Regulation upon Differentiation and Tumor Formation
Recent Lab News
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UC Berkeley Ph.D. students, Franziska Lorbeer from Rheinische Friedrich Wilhelms University Bonn and Timothy Turkalo from University of Kansas, join the lab!
Kunitoshi Chiba gave a talk on transcriptional regulation of endogenous hTERT and John Boyle presented his poster on the role of TPP1 in telomere length homeostasis at the Cold Spring Harbor Laboratory's 2015 meeting on Telomeres and Telomerase!
UC Berkeley freshman in Molecular and Cell Biology, Leslie Chan, joins the lab!
Annual lab photo day!
Congratulations to Tina on completing her masters degree!
Link to lab publications
Title: Genome editing in human pluripotent stem cells using site-specific nucleases
Lab members involved: Kunitoshi Chiba, Dirk Hockemeyer
Title: Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation
Lab members involved: Alec Sexton, Samuel Regalado, Dirk Hockemeyer
Link to research background
Questions to address in regards to telomere maintenance and mechanisms governing telomerase regulation in human pluripotent stem cells:
1) What is the mechanism of telomerase regulation in human stem cells, upon their differentiation and during tumor formation?
2) What are the molecular mechanisms underlying the recruitment of telomerase to the telomere in human cells?
3) What are the consequences of telomere shortening in stem cells and how does this impact tumor formation?
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