Investigating the Repetitive Telomeric DNA Sequence: (TTAGGG)n
Tissue Culture Based Model System: Human Pluripotent Stem Cells
Mechanisms of Telomerase Regulation upon Differentiation and Tumor Formation
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Recent Lab News
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Congratulations to Tim on passing his Qualification Exam for Ph.D. candidacy!
Congratulations to Franzi on passing her Qualification Exam for Ph.D. candidacy!
Congratulations to Josh on the publication of "Human stem cell-based disease modeling: prospects and challenges," a review article in Current Opinon in Cell Biology's themed issue on 'Differentiation and Disease'!
UC Berkeley sophomore in Chemical Biology, Annie Lai, joins the lab!
Link to lab publications
Title: Human stem cell-based disease modeling: prospects and challenges
Lab members involved: Joshua Johnson, Dirk Hockemeyer
Title: Control of telomerase action at human telomeres
Lab members involved: Dirk Hockemeyer
Link to research background
Questions to address in regards to telomere maintenance and mechanisms governing telomerase regulation in human pluripotent stem cells:
1) What is the mechanism of telomerase regulation in human stem cells, upon their differentiation and during tumor formation?
2) What are the molecular mechanisms underlying the recruitment of telomerase to the telomere in human cells?
3) What are the consequences of telomere shortening in stem cells and how does this impact tumor formation?
National Institutes of Health
"The Ellison Medical Foundation supports basic biomedical research on aging relevant to understanding lifespan development processes and age-related diseases and disabilities."
"The purpose of the Glenn Foundation for Medical Research, founded in 1965 by Paul F. Glenn, is to extend the healthy productive years of life through research on the mechanisms of biological aging."
Shurl and Kay Curci Foundation
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