Investigating the Repetitive Telomeric DNA Sequence: (TTAGGG)n
Tissue Culture Based Model System: Human Pluripotent Stem Cells
Mechanisms of Telomere Regulation upon Differentiation and Tumor Formation
Recent Lab News
Access to news archive
September issue of Genes & Development features the latest Hockemeyer lab publication with a Perspective written by Dr. Jan Karlseder.
UC Berkeley graduate in MCB, John Boyle, joins the lab!
Congratulations to Alec on receiving his Ph.D. degree in MCB and on being presented with the Nicholas Cozzarelli Award at the graduation!
Congratulations to Ryan on passing his qualification exam for Ph.D. candidacy!
UC Berkeley Ph.D. student in MCB, Joshua Johnson, joins the lab!
Congratulations to Chiba on passing his qualification exam for Ph.D. candidacy!
Link to lab publications
Title: Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation
Lab members involved: Alec Sexton, Samuel Regalado, Dirk Hockemeyer
Title: Human intestinal tissue with stem cell properties derived from pluripotent stem cells
Lab members involved: Ryan Forster, Kunitoshi Chiba, Samuel Regalado, Dirk Hockemeyer
Link to research background
Questions to address in regards to telomere regulation and mechanisms governing telomerase activity in human pluripotent stem cells:
1) What is the mechanism of telomerase regulation in human stem cells, upon their differentiation and during tumor formation?
2) What are the molecular mechanisms underlying the recruitment of telomerase to the telomere in human cells?
3) What are the consequences of telomere shortening in stem cells and how does this impact tumor formation?
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