Investigating the Repetitive Telomeric DNA Sequence: (TTAGGG)n
Tissue Culture Based Model System: Human Pluripotent Stem Cells
Mechanisms of Telomerase Regulation upon Differentiation and Tumor Formation
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UC Berkeley sophomore in Molecular and Cell Biology, Rayyan Aburajab, joins the lab!
John's last day!
UC Davis graduate in Genetics, Kelsey Hennick, joins the lab!
UC Berkeley senior in Molecular and Cell Biology, Christian Gonzalez, joins the lab!
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Title: Induced Pluripotent Stem Cells Meet Genome Editing
Lab members involved: Dirk Hockemeyer
Title: Human stem cell-based disease modeling: prospects and challenges
Lab members involved: Joshua Johnson, Dirk Hockemeyer
Link to research background
Questions to address in regards to telomere maintenance and mechanisms governing telomerase regulation in human pluripotent stem cells:
1) What is the mechanism of telomerase regulation in human stem cells, upon their differentiation and during tumor formation?
2) What are the molecular mechanisms underlying the recruitment of telomerase to the telomere in human cells?
3) What are the consequences of telomere shortening in stem cells and how does this impact tumor formation?
The Pew Charitable Trusts:
Pew-Stewart Program for Cancer Research
National Institutes of Health
"The Ellison Medical Foundation supports basic biomedical research on aging relevant to understanding lifespan development processes and age-related diseases and disabilities."
"The purpose of the Glenn Foundation for Medical Research, founded in 1965 by Paul F. Glenn, is to extend the healthy productive years of life through research on the mechanisms of biological aging."
Shurl and Kay Curci Foundation
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