(Last year's journal club schedule, papers, and paper bank can be found here)
Procedures:
• We will start promptly at 9AM in 547 LSA. This is because there is another meeting at 10. Please be on time.
• Out of respect to the presenters, members are expected to attend journal club regularly.
• Each member presents 1-2 times per year.
• The week that you present, you should send the organizer the link to the paper you've chosen--ideally on Tuesday, by Wednesday at the latest, so that people have time to look at it before we meet. The goal here is to have the group ready to contribute to a good discussion.
• The week after you present, you are asked to bring snacks for the group.
• If you come across a paper that you'd like to see presented at journal club, you can send me the citation for our Paper Bank, a list of papers to which upcoming presenters can refer for suggestions.
Paper/Presentation guidelines:
1. Since the majority of participants are from vertebrate labs, Developmental Biology Journal Club focuses on vertebrate developmental biology. However, papers from invertebrate systems and/or that yield evolutionary insights are more than welcome, provided they fall within guideline #2. Historically we have presented papers that use Drosophila, C. elegans and other non-vertebrate systems to provide new mechanistic insight into signaling pathways.
2. We ask that papers be chosen based on one of several parameters: mechanistic insight, new technologies and tools, or if not one of those, a paper that has an interesting insight with broad application to the participants. We would like to stick to papers that really get at the mechanisms and signaling patterns driving developmental biology. If you find a paper you'd really like to present but consists simply of expression patterns, we ask that you also present a related mechanism paper to accompany it.
3. Presenters should briefly state why the paper or question being asked is important or applicable to the group. Is it groundbreaking work? Does it provide a new insight into how a signaling pathway works? Why is it important that we read this paper? ("I needed to pick a paper to present" is not a good reason.)
4. Your presentation should include some brief background that is relevant to the paper, such as a summary of what is known about the process/tissue being discussed, of the signaling pathway being studied, or of the line of research from which this paper is derived.
PAPER BANK
• The Msx1 Homeoprotein Recruits Polycomb to the Nuclear Periphery during Development.
Wang et al. Dev Cell. 2011 Sep 13;21(3):575-88.
• Two additional midline barriers function with midline lefty1 expression to maintain asymmetric Nodal signaling during left-right axis specification in zebrafish.
Lenhart et al. Development. 2011 Oct;138(20):4405-10.
• Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish.
Zhu et al. Development. 2011 Oct;138(20):4555-64.
• The dynamic architecture of Hox gene clusters.
Noordermeer et al. Science. 2011 Oct 14;334(6053):222-5.
• Protein Kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube.
Tuson, He, & Anderson. Development. 2011 Nov;138(22):4921-30.
• Novel functions of Noggin proteins: inhibition of Activin/Nodal and Wnt signaling.
Bayramov et al. Development. 2011 Dec;138(24):5345-56.
• Phosphorylation of Mad controls competition between wingless and BMP signaling.
Eivers et al. Sci Signal. 2011 Oct 11;4(194):ra68.
• Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord.
Le Dréau et al. Development. 2012 Jan;139(2):259-68.
• Synchronous and symmetric migration of Drosophila caudal visceral mesoderm cells requires dual input by two FGF ligands.
Kadam, Ghosh, & Stathopoulos. Development. 2012 Feb;139(4):699-708.
• Pitx1 is necessary for normal initiation of hindlimb outgrowth through regulation of Tbx4 expression and shapes hindlimb morphologies via targeted growth control.
Duboc & Logan. Development. 2011 Dec;138(24):5301-9.
• Sequential signaling crosstalk regulates endomesoderm segregation in sea urchin embryos.
Sethi et al. Science. 2012 Feb 3;335(6068):590-3.
• Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube.
Tuson & Anderson. Development. 2011 Nov;138(22):4921-30.
• Turning gene function ON and OFF using sense and antisense photo-morpholinos in zebrafish.
Tallafuss et al. Development. 2012 May; 139:1691-99.
• Dynamic in vivo binding of transcription factors to cis-regulatory modules of cer and gsc in the stepwise formation of the Spemann-Mangold organizer.
Sudou et al. Development. 2012 May; 139: 1651-61.
• GLI3 Constrains Digit Number by Controlling Both Progenitor Proliferation and BMP-Dependent Exit to Chondrogenesis.
Lopez-Rios et al. Dev Cell. 2012 Mar 28. [Epub ahead of print].
Please send all comments, questions, and Paper Bank submissions to Jess Lyons. Thanks!