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Research interests:
Gastric acid is secreted by parietal cells (also called oxyntic cells) in glands of the stomach lining. This lab has been studying various aspects of parietal cell structure and function for four decades, making the initial discovery {1967} of a K+-stimulated, ouabain-insensitive ATPase activity associated with gastric acid secretion — H,K-ATPase, the molecular "proton pump" — and proposing that a membrane recycling process moves these pumps between active and inactive membrane domains {1977, 1981}. In addition, the lab has been studying details of the H,K-ATPase enzymatic cycle, structure and function of the highly glycosylated β-subunit of the H,K-ATPase, synthesis and processing of H,K-ATPase, intracellular signal transduction, ion transport pathways, mechanisms of vesicular fusion and endocytosis, and involvement of the cytoskeleton and cytoskeletal linking proteins in the dynamic morphological changes in the parietal cell with stimulation.
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Model of the morphological and functional rearrangement of the parietal cell between inactive and secreting states.
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Selected publications.
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