Our overall goal is to characterize the cell signaling pathways that inhibit the uncontrolled growth of epithelial-derived tumor cells, the cell type of most human cancers. Molecular, genetic and cell biological experimental strategies are being utilized to explore the mechanisms by which extracellular signals (such as steroid hormones, growth factors and certain dietary and nondietary phytochemicals) coordinately regulate the proliferation and cell-cell interactions of reproductive tumor cells.