Scientific Papers

Duesberg P, Iacobuzio-Donahue C, Brosnan JA, McCormack A, Mandrioli D, Chen L. Origin of metastases: subspecies of cancers generated by intrinsic karyotypic variations. Cell Cycle. 2012 Mar 15;11(6):1151-66. Epub 2012 Mar 15. Link

Duesberg PH, Mandrioli D, McCormack A, Nicholson JM, Rasnick D, Fiala C, Koehnlein C, Bauer HH, Ruggiero M. AIDS since 1984: no evidence for a new, viral epidemic--not even in Africa. Ital J Anat Embryol. 2011;116(2):73-92. Review. Link

Duesberg P, Mandrioli D, McCormack A, Nicholson JM. Is carcinogenesis a form of speciation? Cell Cycle. 2011 Jul 1;10(13):2100-14. Epub 2011 Jul 1. Link

Giehl M, Leitner A, Haferlach C, Duesberg P, Hofmann WK, Hofheinz R, Seifarth W, Hochhaus A, Fabarius A. Detection of centrosome aberrations in disease-unrelated cells from patients with tumor treated with tyrosine kinase inhibitors. Eur J Haematol. 2010 Aug;85(2):139-48. Epub 2010 Apr 16. Link

Klein A, Li N, Nicholson JM, McCormack AA, Graessmann A, Duesberg P. Cancer Genet Cytogenet. Transgenic oncogenes induce oncogene-independent cancers with individual karyotypes and phenotypes.2010 Jul 15;200(2):79-99. Link

Nicholson JM, Duesberg P., On the karyotypic origin and evolution of cancer cells, Cancer Genet Cytogenet. 2009 Oct 15;194(2):96-110. Link

Li L, McCormack AA, Nicholson JM, Fabarius A, Hehlmann R, Sachs RK, Duesberg PH., Cancer-causing karyotypes: chromosomal equilibria between destabilizing aneuploidy and stabilizing selection for oncogenic function.
Cancer Genet Cytogenet. 2009 Jan 1;188(1):1-25. Link

Fabarius A, Li R, Yerganian G, Hehlmann R, Duesberg P., Specific clones of spontaneously evolving karyotypes generate individuality of cancers.
Cancer Genet Cytogenet. 2008 Jan 15;180(2):89-99. Link

P. Duesberg, Chromosomal chaos and cancer, Sci Am 296 (2007), pp. 52-59. PDF

P. Duesberg, R. Li, A. Fabarius and R. Hehlmann, Orders of magnitude change in phenotype rate caused by mutation, Letter: Cell Oncol 29 (2007), pp. 71-72. PDF

P. Duesberg, R. Li, R. Sachs, A. Fabarius, M.B. Upender and R. Hehlmann, Cancer drug resistance: The central role of the karyotype, Drug Resist Updat 10 (2007), pp. 51-58. PDF

A. Fabarius, M. Giehl, O. Frank, B. Spiess, C. Zheng, M.C. Muller, C. Weiss, P. Duesberg, R. Hehlmann, A. Hochhaus and W. Seifarth, Centrosome aberrations after nilotinib and imatinib treatment in vitro are associated with mitotic spindle defects and genetic instability, Br J Haematol 138 (2007), pp. 369-373. PDF

Duesberg, P., Li, R., Fabarius, A. and Hehlmann, R.  Aneuploidy and Cancer:  From Correlation to Causation. Contrib Microbiol. (Basel, Krager) vol. 13, 16-44 (2006).  PDF

Fabarius, A., Giehl, M., Frank, O., Duesberg, P., Houchhaus, A.,  Hehlmann, R., and Seifarth, W. Induction of centrosome and chromosome aberrations by imatinib in vitro. Leukemia 9, 1573-1578 (2005). PDF

Duesberg, P., Li, R., Fabarius, A. and Hehlmann, R.  The chromosomal basis of cancer.  Cellular Oncology 27, 293-318 (2005). PDF

Li, R., Hehlmann, R., Sachs, R. and Duesberg, P. Chromosomal alterations cause the high rates and wild ranges of drug resistance in cancer cells. Cancer Genet Cytogenet 163, 44-56 (2005). PDF

Duesberg, P. Does aneuploidy or mutation start cancer? Science 307(5706), 41 (2005). PDF

Duesberg, P., Fabarius, A. & Hehlmann, R. Aneuploidy, the primary cause of the multilateral genomic instability of neoplastic and preneoplastic cells.
IUBMB Life 56, 65-81. (2004) PDF

Duesberg, P., Li, R. and Rasnick, D.  Aneuploidy approaching a perfect score in predicting and preventing cancer.  Cell Cycle 3, 823-828 (2004).  PDF

Duesberg, P., and Li, R. Multistep carcinogenesis: a chain reaction of aneuploidizations. Cell Cycle 2, 202-210 (2003). PDF

Duesberg, P. H. Are cancers dependent on oncogenes or on aneuploidy? Cancer Genet Cytogenet 143, 89-91 (2003). Link

Fabarius, A., Hehlmann, R., and Duesberg, P. H.  Instability of chromosome structure in cancer cells increases exponentially with degrees of aneuploidy. Cancer Genet Cytogenet 143, 59-72 (2003). Link

Li, R., D. Rasnick, and P. Duesberg. Correspondence re: D. Zimonjic et al., Derivation of human tumor cells in vitro without widespread genomic instability. Cancer Res., 61: 8838-8844, 2001. Cancer Res. 62:6345-8; author reply 6348-9 (2002).  PDF

Fabarius, A., Willer, A., Yerganian, G., Hehlmann, R., and Duesberg, P.: Specific aneusomies in Chinese hamster cells at different stages of neoplastic transformation, initiated by nitrosomethylurea. Proceedings of the National Academy of Sciences of the United States of America 99, 6778-6783 (2002).  Link

Duesberg, P., Stindl, R., Li, R. H., Hehlmann, R. & Rasnick, D.: Aneuploidy versus gene mutation as cause of cancer. Current Science 81, 490-500 (2001).  [PDF] (1.2Mb!!)

Duesberg, P., Stindl, R. & Hehlmann, R.: Origin of multidrug resistance in cells with and without multidrug resistance genes: Chromosome reassortments catalyzed by aneuploidy. Proceedings of the National Academy of Sciences of the United States of America 98, 11283-11288 (2001).  Link

Duesberg, P., Stindl, R. & Hehlmann, R.: Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalyzed by aneuploidy. Proceedings of the National Academy of Sciences of the United States of America 97, 14295-14300 (2000).  Link

Duesberg, P. & Rasnick, D.: Aneuploidy, the somatic mutation that makes cancer a species of its own. Cell Motility and the Cytoskeleton 47, 81-107 (2000). PDF

Duesberg, P. et al.: Aneuploidy precedes and segregates with chemical carcinogenesis. Cancer Genetics and Cytogenetics 119, 83-93 (2000). PDF

Li, R. H., Sonik, A., Stindl, R., Rasnick, D. & Duesberg, P.: Aneuploidy vs. gene mutation hypothesis of cancer: Recent study claims mutation but is found to support aneuploidy. Proceedings of the National Academy of Sciences of the United States of America 97, 3236-3241 (2000).  Link

Rasnick, D. & Duesberg, P. How aneuploidy affects metabolic control and causes cancer. Biochem J, 340, 621-630 (1999) PDF

Duesberg, P., Rasnick, D., Li, R., Winters, L., Rausch, C., and Hehlmann, R. . How aneuploidy may cause cancer and genetic instability. Anticancer Res 19, 4887-4906 (1999). Link

Duesberg, P.: Are centrosomes or aneuploidy the key to cancer? Science 284, 2091-2092 (1999). PDF

Duesberg, P., Rausch, C., Rasnick, D. & Hehlmann, R.: Genetic instability of cancer cells is proportional to their degree of aneuploidy. Proceedings of the National Academy of Sciences of the United States of America 95, 13692-13697 (1998). PDF

Li, R. H. et al.: Aneuploidy correlated 100% with chemical transformation of Chinese hamster cells. Proceedings of the National Academy of Sciences of the United States of America 94, 14506-14511 (1997). PDF