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Georlette D., Ahn S., MacAlpine D.M., Cheung E, Lewis P.W., Beall E.L., Bell S.P., Speed T, Manak J.R. and Botchan M. Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb-MuvB/dREAM complex in proliferating cells. Genes Dev. 2007. In Press. |
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Beall EL, Lewis PW, Bell M, Rocha M, Jones DL, Botchan MR Discovery of tMAC: a Drosophila testis-specific meiotic arrest complex paralogous to Myb-Muv B. Genes Dev. 2007, 21: 904-919 |
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Botchan, M. Cell Biology: a switch for S phase. Nature. 2007, 445: 272-274. |
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Abbate, E.A., Voitenleitner, C., and Botchan, M.R. Structure of the papillomavirus DNA-tethering complex E2:Brd4 and a peptide that ablates HPV chromosomal association. Mol. Cell. 2006. 24: 877-889. |
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Clarey, M.G., Erzberger, J.P., Grob, P., Leschziner, A.E., Berger, J.M., Nogales, E. and Botchan, M. Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex. Nature Struct. & Mol. Biol. 2006. 13: 684-690. |
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Moyer, S.E.,
Lewis, P.W. and Botchan, M.R. Proc. Natl. Acad. Sci. USA. 2006. 103: 10236-10241. |
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Remus, D., Blanchette, M., Rio, D.C. and Botchan, M.R. Cdk phosphorylation inhibits the DNA-binding and ATP-hydrolysis activities of drosophila ORC. J. Biochem 2005. 280: 39740-39751. |
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Bandura, J.L., Beall, E.L., Bell, M., Silver, H.R., Botchan, M.R. and Calvi, B.R humpty dumpty is required for developmental DNA amplification and cell proliferation in Drosophila. Curr. Biol. 2005. 15: 755-759. |
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Lewis
PW, Beall EL,
Fleischer TC, Georlette D, Link AJ, Botchan MR. Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex. Genes Dev. 2004 Dec 1;18(23):2929-2940. |
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Abbate EA, Berger JM,
Botchan MR. The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2. Genes Dev. 2004 Aug 15;18(16):1981-96. |
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Beall EL, Bell M,
Georlette D, Botchan MR. Dm-myb mutant lethality in Drosophila is dependent upon mip130: positive and negative regulation of DNA replication. Genes Dev. 2004 Jul 15;18(14):1667-80. |
| Remus
D, Beall EL, Botchan MR. DNA topology, not DNA sequence, is a critical determinant for Drosophila ORC-DNA binding. EMBO J. 2004 Feb 25;23(4):897-907 |
| Chesnokov
I, Chesnokova ON, Botchan M. A cytokinetic function of Drosophila ORC6 protein resides in a domain distinct from its replication activities. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9150-5 |
| Beall
EL, Manak JR, Zhou S, Bell M, Lipsick JS, Botchan MR. Role for a Drosophila Myb-containing protein complex in site-specific DNA replication. Nature. 2002 Dec 19-26;420(6917):833-7 |
| Voitenleitner
C, Botchan M. E1 protein of bovine papillomavirus type 1 interferes with E2 protein-mediated tethering of the viral DNA to mitotic chromosomes. J Virol. 2002 Apr;76(7):3440-51. |
| Chesnokov
I, Remus D, Botchan M. Functional analysis of mutant and wild-type Drosophila origin recognition complex. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):11997-2002. |
| Pflumm
MF, Botchan MR. Orc mutants arrest in metaphase with abnormally condensed chromosomes. Development. 2001 May;128(9):1697-707. |
| Parker
LM, Harris S, Gossen M, Botchan MR. The bovine papillomavirus E2 transactivator is stimulated by the E1 initiator through the E2 activation domain. Virology. 2000 May 10;270(2):430-43. |
| Harris
SF, Botchan MR. Crystal structure of the human papillomavirus type 18 E2 activation domain. Science. 1999 Jun 4;284(5420):1673-7 |
| Chesnokov
I, Gossen M, Remus D, Botchan M. Assembly of functionally active Drosophila origin recognition complex from recombinant proteins. Genes Dev. 1999 May 15;13(10):1289-96. |
| Fouts
ET, Yu X, Egelman EH, Botchan MR. Biochemical and electron microscopic image analysis of the hexameric E1 helicase. J Biol Chem. 1999 Feb 12;274(7):4447-58. |
| Lehman
CW, Botchan MR. Segregation of viral plasmids depends on tethering to chromosomes and is regulated by phosphorylation. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4338-43. |
| Lim
DA, Gossen M, Lehman CW, Botchan MR. Competition for DNA binding sites between the short and long forms of E2 dimers underlies repression in bovine papillomavirus type 1 DNA replication control. J Virol. 1998 Mar;72(3):1931-40 |
| Pak
DT, Pflumm M, Chesnokov I, Huang DW, Kellum R, Marr J, Romanowski P,
Botchan MR. Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes. Cell. 1997 Oct 31;91(3):311-23. |