Publications:

Toll-like receptor-deficient mice reveal how innate immune signaling influences salmonella virulence strategies. Sivick KE, Arpaia N, Reiner GL, Lee BL, Russell BR, Barton GM. Cell Host Microbe (2014) 15(2): 203-13

Lee BL, Barton GM. Trafficking of endosomes Toll-like receptors. Trends in Cell Biology (2014) 24(6): 360-369

Koch MA, Barton GM. TLR5 stops commensals in their tracks. Cell Host Microbe (2013) 14(5): 488-90.

Deguine J, Lee BL, Newman ZR, Barton GM. No antigen-presentation defect in Unc93b1(3d/3d) 3d mice. Nature Immunology (2013) 14: 1101-1102.

Lee BL, Moon JE, Shu JH, Yuan L, Newman ZR, Schekman R, Barton GM. UNC93B1 mediates differential trafficking of endosomal TLRs, eLife (2013) 2: e00291.

Arpaia N, Barton GM. The Impact of Toll-like Receptors on Bacterial Virulence Strategies, Current Opinions in Microbiology (2013) 16: 17-22

Chiang C, Engel A, Opaluch AM, Ramos I, Maestre AM, Secundino I, De Jesus P, Nguyen QT, Welch B, Bonamy GM, Miraglia LJ, Orth AP, Nizet V, Fernandez-Sesma A, Zhou Y, Barton GM, Chanda SK. Cofactors Required for TLR7- and TLR9- Dependent innate Immune Responses, Cell Host and Microbe (2012) 35: 306-318.

Mouchess ML, Arpaia N, Souza G, Barbalat R, Ewald SE, Lau L, Barton GM. Transmembrane Mutations in Toll-like Receptor 9 Bypass the Requirement for Ectodomain Proteolysis and Induce Fatal Inflammation, Immunity (2011) 35: 721-732.

Zanoni I, Ostuni R, Marek LR, Barresi S, Barbalat R, Barton GM, Granucci F, Kagan JC. CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4, Cell (2011) 147: 868-880.

Arpaia N, Barton GM. Toll-like receptors: key players in antiviral immunity, Current Opinion in Virology (2011) 1: 447-454.

Barbalat R, Ewald SE, Mouchess ML, Barton GM. Nucleic Acid Recognition by the Innate Immune System, Annual Review of Immunology (2011) 29: 185-214.

Ewald SE, Engel A, Lee J, Wang M, Bogyo M, Barton GM. Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase, Journal of Experimental Medicine (2011) 208: 643-651.

Arpaia N, Godec J, Lau L, Sivick KE, McLaughlin LM, Jones MB, Dracheva T, Peterson SN, Monack DM, Barton GM. TLR signaling is required for Salmonella typimurium virulence, Cell (2011) 144: 675-688.
Video abstract can be found here.

Barbalat R, Lau L, Locksley RM, Barton GM. Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands, Nature Immunology (2009) 10: 1200-1207.

Barton GM, Kagan JC. A cell biological view of Toll-like receptor function: regulation through compartmentalization, Nature Reviews Immunology (2009) 9: 535-542

Ewald SE, Lee BL, Lau L, Wickliffe KE, Shi GP, Chapman HA, Barton GM. The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor, Nature (2008) 456: 658-662.


Barton GM. A calculated response: control of inflammation by the innate immune system, J. Clin. Invest. (2008) 118: 413-420.

Barton GM. Viral recognition by Toll-like receptors, Semin. Immunol. (2007) 19:33-40.