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David Savage

David Savage

Assistant Professor of Biochemistry, Biophysics and Structural Biology

Lab Homepage: http://savagelab.org

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Research Interests

The molecules used to build cells, and much of human infrastructure, are synthesized by the chemical reactions of metabolism. In understanding metabolism better, we open the door to new ways of curing disease and environmentally friendly chemistry. Work in our lab focuses on defining how metabolic reactions function in the context of the cellular system in order to elucidate the so-called design principles of metabolic function. To do so, we take an interdisciplinary approach, combining biochemistry, biophysics, and systems biology, with an eye towards building synthetic biology tools.

Selected Publications

Bonacci, Walter, Poh K Teng, Bruno Afonso, Henrike Niederholtmeyer, Patricia Grob, Pamela A Silver, and David F Savage. 2012. “Modularity of a Carbon-Fixing Protein Organelle..” Proceedings of the National Academy of Sciences of the United States of America 109 (2) (January 10): 478–483. doi:10.1073/pnas.1108557109.

Niederholtmeyer, H, B T Wolfstadter, D F Savage, P A Silver, and J C Way. 2010. “Engineering Cyanobacteria to Synthesize and Export Hydrophilic Products.” Applied and Environmental Microbiology 76 (11) (May 19): 3462–3466. doi:10.1128/AEM.00202-10.

Savage, David F, Bruno Afonso, Anna H Chen, and Pamela A Silver. 2010. “Spatially Ordered Dynamics of the Bacterial Carbon Fixation Machinery..” Science (New York, N.Y.) 327 (5970) (March 5): 1258–1261. doi:10.1126/science.1186090.

Defossiling fuel: How synthetic biology can transform biofuel production. Savage, D.F., Way, J., Silver, P.A. (2008) ACS Chem. Biol. 3:13-6.

Cell-free complements in vivo expression of the E. coli membrane proteome. Savage, D.F., Anderson C.L, Robles-Colmenares, Y., Newby, Z.A., Stroud R.M. (2007) Protein Sci. 16:966-76. 

Substrate twinning activates the signal recognition particle and its receptor. Egea P.F., Shan S.O., Napetschnig J., Savage D.F., Walter P., Stroud R.M. (2004) Nature, 426:215-221.

 

Last Updated 2012-01-29