Department of Molecular & Cell Biology

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Richard Calendar

Richard Calendar

Professor of the Graduate School Division of Biochemistry, Biophysics and Structural Biology

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Research Interests

We are constructing a plasmid vector that will allow insertion of any gene of interest at a defined site on the Bacillus anthracis chromosome. We are characterizing a new class of B. cereus/anthracis phages that may be used for bio-control.

Current Projects

We are constructing an integration vector--a plasmid that can insert in the B. anthracis chromosome--that will allow us to express particular antigens of B. anthracis at a high level. The new phages that we are characterizing are extremely virulent. We intend to determine why this is so.

Selected Publications

Comparative genome analysis of Listeria bacteriophages reveals extensive mosaicism, programmed translational frameshifting, and a novel prophage insertion site. J. Dorscht, J. Klumpp, R. Bielmann, M. Schmelcher, Y. Born, M. Zimmer, R. Calendar and M. J. Loessner. J. Bacteriol 191:7206-7215, 2009.

Killed but metabolically active Bacillus anthracis vaccines induce broad and protective immunity against anthrax. J. Skoble, J. W. Beaber, Y. Gao, J. A. Lovchik, L. E. Sower, W. Liu, W. Luckett, J. W. Peterson, R. Calendar, D. A. Portnoy, C. R. Lyons, and T. W. Dubensky. Infection and Immunity 77:1649-1673, 2009.

Terminally Redundant, non-permuted Genome of Listeria Bacteriophage A511: a Model for the SPO1-like Myoviruses of Gram-Positive Bacteria. J. Klumpp, J. Dorscht, R. Lurz, R. Bielmann, M. Wieland, M. Zimmer, R. Calendar, and M. J. Loessner. J. Bacteriol. 190:5753-5765, 2008.

A stable integration vector for nutritional selection of recombinant antigen expression by attenuated Listeria monocytogenes. L. A. Lenz, W. A. Huang, Chenhui Zhou, Zhongxia Li, and R. Calendar. Clin. Vaccine Immunol. 15:1414-1419, 2008.

Molecular characterization of L-413C, a P2-related plague diagnostic bacteriophage. E. Garcia, P. Chain, J. M. Elliott, A. G. Bobrov, V. L. Motin, O. Kirillina, V. Lao, R. Calendar and A. A. Filippov. Virology 372:85-96, 2008.

The Bacteriophages. R. Calendar, Editor. Oxford University Press, New York, 2006.

Bacteriophage Biology. R. Calendar and R. B. Inman. In Phages: Their Role in Bacterial Pathogenesis and Biotechnology," Ed. M. Waldor, D. Friedman and D. Court, American Society for Microbiology, Washington, D.C., 2005.

Construction, Characterization, and Use of two Listeria monocytogenes site-specific phage integration vectors. P. Lauer, M. Chow, M. J. Loessner, D. Portnoy, and R. Calendar.  J. Bacteriol. 184: 4177-4186, 2002.

Gene insertion and replacement in Schizosaccharomyces pombe mediated by the Streptomyces bacteriophage phiC31 site-specific recombination system Lynn C. Thomason, Richard Calendar, and David W. Ow. Molecular Genetics and Genomics 265:1031-1038, 2001.

Last Updated 2011-08-18