Microtubule-driven self-assembly of the Dam1 kinetochore ring.

The yeast kinetochore complex Dam1 self-assembles around microtubules forming rings that can diffuse on the microtubule lattice and harvest the energy of microtubule disassembly to move processively towards the poles during anaphase.

(These studies are being carried out as a collaboration of three MCB faculty members: Georjana Barnes, David Drubin and Eva Nogales)