A single amino acid change in Fas-associated Death Domain affects mouse physiology and cell cycle progression.
The illustration depicts a wild type mouse and a littermate mutant mouse
expressing a constitutive serine phosphorylation mutation in Fas-Associated
Death Domain (FADD-D). FADD-D mice exhibit reduced body size. The
corresponding confocal images show mislocalization of FADD-D protein.
Activated T cells from either wild type or FADD-D mice were stained with
FADD antibody (green and pink, respectively) and DAPI (blue).