Faculty Research Page

Fyodor Urnov

Fyodor Urnov

Adjunct Professor of Genetics, Genomics and Development

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Research Interests

Development of novel therapeutic approaches to monogenic diseases using targeted intervention with the sequence and function of the human genome:

- genome editing using engineered zinc finger nucleases

- targeted regulation of gene expression using engineered zinc finger protein transcription factors

Current Projects

1. Genome editing in hematopoietic stem cells using zinc finger nucleases as a treatment for the hemoglobinopathies (beta-thalassemia and sickle cell disease).

2. Targeted, allele-specific repression of mutant huntingtin in the forebrain using an engineered zinc finger protein repressor as a treatment for Huntington's disease.

3. Teaching MCB 140 (upper-division genetics) in the Fall semesters, and (with Professor Jasper Rine) a class called Biology for Voters.

Selected Publications

Urnov, F.D., Miller, J.C., Lee, Y.-L., Beausejour, C.M., Rock, J.M., Augustus, S., Jamieson, A.C., Porteus, M.H., Gregory, P.D., and Holmes, M.C. (2005). Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature 435, 646–651.

Urnov, F.D., Rebar, E.J., Holmes, M.C., Zhang, H.S., and Gregory, P.D. (2010). Genome editing with engineered zinc finger nucleases. Nat. Rev. Genet. 11, 636–646.

Last Updated 2014-01-08