MCB 231 Spring 2010
Lectures: Tuesdays and Thursdays 11:00-12:30 2062 VLSB
Discussions: Fridays 12:00-1:00 TBD
INSTRUCTORS (See *** for administrative matters related to this course):
Richard Harland firstname.lastname@example.org
Lin He email@example.com
David Weisblat firstname.lastname@example.org
There is no required text. For review or background:
Slack "Essential Developmental Biology", 2nd edition, Blackwell
Gilbert "Developmental Biology" 6th, 7th, or 8th edition, Sinauer (the 6th edition is available online).
Gilbert & Raunio "Embryology: Constructing the Organism" Sinauer
Moody "Cell Lineage and Fate Determination" Academic Press
Wolpert "Principles of Development" Current Biology/Oxford
Each discussion section will consist of student presentations of 1-2 assigned research articles relevant to the concurrent lectures. At our first meeting, we will choose presentation dates and briefly discuss how to give an effective presentation. The discussion papers will be assigned as the course progresses and will typically be assigned at least one week prior to discussion.
You should present a critical evaluation of the paper, as in a 290 seminar (which most of you haven't taken yet!). Although the entire class must read the paper prior to discussion, you should treat your presentation as though we have not. As you prepare your presentation, it will probably become clear that you need to read additional papers (for background knowledge or to clarify previous work that the paper is based on) – you are expected to do this additional reading.
Your presentation should be organized as follows:
- Background: put the paper in context.
- Statement of the main points and claims of the paper.
- Detailed consideration of the methods and data: usually this takes the form of going through the figures, discussing each not in general terms but pointing out salient features ("if you compare lane A and G of the figure you see that....")
- Discussion of whether the work is convincing, how well presented it was, how clear, whether the conclusions are justified, what more you would have liked to see, how this fits with present day notions. Was the work important or overblown?
The whole presentation, including discussion, should take about 30-45 minutes so that the whole section should take an hour, depending upon the number of papers presented. Members of the class are expected to participate in a **lively** discussion. Powerpoint presentations are standard to present the data, but you are strongly encouraged to make use of the blackboard during the discussion.
Grades will be assigned on the basis of: your oral presentation(s) and participation in Discussions your written assignment by Prof. Harland, He and Weisblat. The ground rules to be discussed at the start of the course.
PLAGIARISM (COPYING TEXT OR FIGURES from any source, whether printed or online, without attribution) will result in automatic failure, with referral for further disciplinary action at the University level.
MCB231 Spring 2010 Schedule
Lecture: Tu Th 11-12:30 2062 VLSB;
Discussion: F, 12-1 2032 VLSB
Tu Jan 19 GG GG Mechanisms of asymmetric cell division Th Jan 21 GG Mechanisms of asymmetric cell division F Jan 22 Discussion section organizational meeting Tu Jan 26 GG Regulation of cell migration and axon guidance Th Jan 28 GG Regulation of cell migration and axon guidance F Jan 29 Discussion Tu Feb 2 RH Amphibian development: cell movements, determinants and inductions Th Feb 4 RH Symmetry breaking and mesoderm induction F Feb 5 Discussion Tu Feb 9 RH The organizer and neural induction Th Feb 11 RH Morphogenesis, Planar cell polarity, cell rearrangements and shape changes F Feb 12 Discussion Tu Feb 16 LH pre-implantation development in mouse Th Feb 18 LH ES cell biology F Feb 19 Discussion Tu Feb 23 LH iPS cell biology Th Feb 25 LH Genetic tools to study mouse development and disease F Feb 26 Discussion Tu Mar 2 RH Amniote gastrulation movements Th Mar 4 RH Axial patterning and nodal signaling F Mar 5 Discussion Tu Mar 9 RH spinal cord patterning Th Mar 11 RH formation and differentiation of somites F Mar 12 Discussion Tu Mar 16 LH Limb development Th Mar 18 LH Limb development W Mar 19 Discussion (Spring break Mar 22-26) Tu Mar 30 LH small ncRNA functions in development Th Apr 1 LH small ncRNA functions in development F Apr 2 Discussion Tu Apr 6 NP The Evolution of Body Patterning Th Apr 8 IH The Evolution of Body Patterning F Apr 9 Discussion Tu Apr 13 JG Sea urchin (Echinoderm) Development Th Apr 15 FW Hemichordates and the origin of chordates F Apr 16 Discussion Tu Apr 20 DW Spiralian development: D quadrant specification Th Apr 22 DW Spiralian development: segmentation F Apr 23 Discussion Tu Apr 27 DW Spiralian development: segmentation Th Apr 29 DW Spiralian development: dorsoventral patterning F Apr 30 Discussion Tu May 4 DW Spiralian development: stem cells and regeneration Th May 6 DW Spiralian development: stem cells and regeneration F May 7 Discussion