S. Linn, D. Rio & J. Thorner, instructors
| Lecture | Month | Date | Lecturer | Topics |
|---|---|---|---|---|
| 1 | Aug | 28 | SL | Course Introduction; Some chemistry, biochemistry and pharmacology of the nucleotides. |
| 2 | 30 | SL | Properties and higher order structures of DNA. | |
| Sept | 3 | LABOR DAY HOLIDAY | ||
| 3 | 4 | SL | Properties, structures, and functions of RNAs. | |
| 4 | 6 | SL | Chromatin - nucleosome structure, modifications, and remodeling. | |
| 5 | 11 | SL | DNA replication I - general themes and the DNA polymerases. | |
| 6 | 13 | SL | DNA replication II. | |
| 7 | 18 | SL | Other enzymes that act on DNA - properties, in vivo function, and applications in the research laboratory. | |
| 8 | 20 | SL | Reactive oxygen species (oxygen-containing radicals) - roles in DNA damage, aging, and disease. | |
| 9 | 25 | SL | Repair of DNA damage I - types of DNA damage and their repair pathways. | |
| 10 | 27 | SL | Repair of DNA damage II - responses to DNA damage. |
| Exam | Oct | 1 | Mon | EXAM #1 6:00 - 8:30 pm, Room 2040, VLSB |
| Lecture | Month | Date | Lecturer | Topics |
| 11 | Oct | 2 | DR | General recombination and the relation to homologous DNA repair; site-specific recombination. |
| 12 | 4 | DR | Retrovirus integration, transposition, V(D)J recombination, other DNA rearrangements. |
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| 13 | 9 | DR | Prokaryotic mechanisms of transcription and its regulation. | |
| 14 | 11 | DR | The eukaryotic transcriptional machinery and chromatin in gene regulation. | |
| 15 | 16 | DR | Enhancers, activators and repression. |
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| 16 | 18 | DR | Transcription in signal transduction and development. |
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| 17 | 23 | DR | Pre-mRNA splicing - discovery, mechanism, fidelity and specificity. | |
| 18 | 25 | DR | RNA binding proteins, alternative splicing, regulation of splice site selection and genome-wide approaches. |
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| 19 | 30 | DR | Catalytic RNA, ribozymes and aptamers. |
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| 20 | Nov | 1 | DR | Non-coding RNAs, RNA editing, RNA interference (RNAi), microRNAs and piRNAs. |
| Exam | Nov | 5 | Mon | EXAM #2 6:00 - 8:30 pm, Room 2040, VLSB |
| Lecture | Month | Date | Lecturere | Topics |
| 21 | Nov | 6 | JT | Mechanisms in nucleocytoplasmic trafficking and its control. |
| 22 | 8 | JT | Protein synthesis and regulation of translation. | |
| Nov | 12 | VETERAN'S DAY HOLIDAY | ||
| 23 | 13 | JT | Protein folding and acquisition of protein function in vivo. | |
| 24 | 15 | JT | Protein precursor processing and regulation of protein degradation. | |
| 25 | 20 | JT | Signal transduction biochemistry: receptors, scaffolds, adaptors and second messengers. | |
| Nov | 22-23 | THANKSGIVING HOLIDAY | ||
| 26 | 27 | JT | Structure, mechanism, function and regulation of G proteins. | |
| 27 | 29 | JT | Structure, mechanism, function and regulation of protein kinases. | |
| 28 | Dec | 4 | JT | Structure, mechanism, function and regulation of phosphoprotein phosphatases. |
| 29 | 6 | JT | Modulation of transcription by signaling pathways. | |
| 30 | 11 | JT | The eukaryotic cell cycle, growth control and apoptosis. |
| Exam | Dec | 19 | Wed | EXAM #3 12:30 - 3:00 PM, Location 534 Davis Hall |