MCB150   MOLECULAR IMMUNOLOGY

                                      Fall 2006

 

              Molecular and Cell Biology 150 is a general introduction to the field of molecular immunology. We will focus on the basic concepts and experimental approaches to molecular immunology including topics that are currently controversial and under active investigation. We anticipate that this course will provide a foundation for advanced work in immunology and will enable you to read and evaluate the scientific and popular immunological literature. We also hope that it will be helpful to those who wish to use immunological  approaches to answer experimental questions in other disciplines of biology.

              Although  much of the experimental work upon which concepts presented in this course has been done in animals (primarily mice), we will whenever possible provide examples of relevant  applications  to the human immune system.

 

 

                                                        Instructors:

 

Ellen Robey

Gregory Barton

Robert Beatty

 

471A  LSA

 

405 LSA

 

176 LSA

642-8669

642-2083

642-0671

Office Hours:

Tues 11-12

ear_admin@berkeley.edu

Office Hours:

Thursday: 4-5 PM

 

Office Hours:

Friday: 2-3 PM

FAX: 643-9500

FAX: 643-4128

FAX: 643-6791

 

                                           Graduate Student Instructors:

 

Sarah Ewald

Maria Mouchess

 

Office Hours:   Wed 12-1

                        448 LSA

 

Office Hours:   Thurs 1-2pm

                       448 LSA

 

e-mail: see150@gmail.com

 

e-mail: mcb150.maria@gmail.com

 

Announcements:

                                                      EXTRA FINAL OH:

                                                      Prof. Beatty:           12/12 3-4pm 176 LSA

                                                                                     12/13 3:30-5:30pm 177 LSA

 

                                                      Prof. Robey: Tues Dec 12 11-12pm 471A LSA

 

                                                      Prof. Barton: Wed Dec 13 4-5pm 405 LSA

 

                                                      Sarah: Finals week 12/11 Monday 10-11pm 547 LSA

                                                               12/13 Wednesday 12-1pm  448 LSA

                                                      Maria: Finals week 12/11 Monday 1-2pm 448 LSA

                                                                                     12/12 Tuesday 5-6:30 pm MaeÕs Coffeehouse (on Shattuck b/w Addison and Center St)                                                                  

                                                     

 

Midterm I and II key is posted in the glass case across from 2083-2095 VLSB

              Please pick up your exam if you have not done so already.

 

                                                                      Lectures:

 

Tuesday/Thursday: 9:30-11:00 AM, 2040 VLSB

 

                                                 Discussion Sections:

 

                  Monday 9-10AM            106 Moffitt          Sarah

                  Tuesday 3-4 PM             340 Moffitt          Sarah   

                  Wednesday 11-12 AM     103 Moffitt         Maria

                  Thursday 2-3 AM            340 Moffitt         Maria

 

 

 

 

 

Course Syllabus:                   syllabus.pdf

Course Schedule:                  schedule.pdf

 

Aug. 29th, Lecture 1 Overview and Innate Immunity:

lecture1.pdf       lecture1.htm

 

Aug. 31st, Lecture 2 Innate Immunity and Antibodies I:

lecture2.pdf       lecture2.htm

 

Sept. 5th, Lecture 3 Antigens and Antibodies II:

lecture3.pdf       lecture3.htm

 

Sept. 7th, Lecture 4 Antigens and Antibodies III/ Imm. techniques:

lecture4.pdf       lecture4.htm

 

Sept. 12th, Lecture 5 Immunological Techniques/ V(D)J recombination:

lecture5.pdf       lecture5.htm     Pregnancy test movie

 

Sept. 14th, Lecture 6 V(D)J recombination/ B cell dev.:

lecture6.pdf       lecture6.htm

 

Sept. 19th, Lecture 7 B cell dev. and tolerance:

lecture7.pdf       lecture7.htm

 

Sept. 21st, Lecture 8 B cell immune response:

lecture8.pdf       lecture8.htm

 

Sept. 28th, Lecture 9: MHC restriction/Genetics of the immune response

lecture9.pdf       lecture9.htm

 

Oct. 3rd, Lecture 10: Antigen Processing: Class I and Class II pathways

lecture10.pdf    lecture10.htm

 

Oct. 5th, Lecture 11: TCR structure and signaling

lecture11.pdf    lecture11.htm

 

Oct. 10th, Lecture 12: T cell development I

lecture 12.pdf  lecture12.htm

 

Oct. 12th, Lecture 13: T cell development II

lecture 13.pdf  lecture13.htm

 

Oct. 17th, Lecture 14: Costimulation and Peripheral tolerance

lecture 14.pdf  lecture14.htm

 

Oct. 19th, Lecture 15: Interactions between innate and adaptive immunity

lecture 15.pdf  lecture15.htm

 

Oct. 24th, Lecture 16: Cytotoxic T cells and NK cells

lecture 16.pdf  lecture16.htm

 

Oct. 26th, Lecture 17: Cytokines and Th subsets

lecture 17.pdf  lecture17.htm

 

Oct. 31th, Lecture 18: Humoral Immunity and Complement

lecture 18.pdf  lecture18.htm

 

Nov. 7th, Lecture 19: Inflammation and cytokines

lecture 19.pdf  lecture19.htm

 

Nov. 9th, Lecture 20: Hypersensitivity

lecture 20.pdf  lecture20.htm

 

Nov. 14th, Lecture 21: Immune response to infection: innate immunity

lecture 21.pdf  lecture21.htm

 

Nov. 16th, Lecture 22: Immune response to infection: adaptive immunity

lecture 22.pdf  lecture22.htm

 

Nov. 21th, Lecture 23: Vaccines

lecture 23.pdf  lecture23.htm

 

Nov. 28th, Lecture 24: HIV/AIDS

lecture 24.pdf  lecture24.htm

 

Nov. 30th, Lecture 25: Autoimmunity

lecture 25.pdf  lecture25.htm

 

Dec. 5th, Lecture 26: Transplantation

lecture 26.pdf  lecture26.htm

 

 

 

Problem sets – Prof. Robey:

Problem Set 1                   Problem Set 1 Key

Problem Set 2                   Problem Set 2 Key

Problem Set 3                   Problem Set 3 Key

Problem Set 4                    Problem Set 4 Key

                                                                       

Practice Midterm 1

Practice Midterm Key 1

 

Problem sets – Prof. Barton:

Problem set 5                     Problem set 5 key

Problem set 6                     Problem set 6 key

Problem set 7                     Problem set 7 key

Problem set 8                     Problem set 8 key

Problem set 9                     Problem set 9 key

 

Problem sets – Prof. Beatty:

Problem set 10                  Problem set 10 key

Problem set 11                  Problem set 11 key

Problem set 12                  Problem set 12 key

 

 

 

Papers for discussion

For Midterm I: Akira00.pdf    

For Midterm II: Aire discussion paper

For Final:           Doherty Flu review (background info)

                                    La Gruta PNAS disc paper

 

Other:

Week 4 discussion handout