Referenced Textbook (recommended, not required): Scott F. Gilbert, Developmental Biology, Ninth (2010) or Eighth Edition (2006)
I. Professor Michael Levine
First third of the course: Introduction to developmental biology, patterning of the Drosophila embryo
Lecture 1, Tuesday, Jan 20. Nuclear equivalence and reprogramming. (lecture notes, supplemental reading, Pubmed for Yamanaka iPS cell paper)
Lecture 2, Thursday, Jan 22. Summary of regulatory mechanisms. (lecture notes, supplemental reading)
Lecture 3, Tuesday, Jan 27. Segmentation of the Drosophila embryo. (lecture notes)
Lecture 4, Thursday, Jan 29. Germ cells and oogenesis. (lecture notes)
Lecture 5, Tuesday, Feb 3. Dorsal-ventral patterning of the Drosophila embryo. (lecture notes)
Lecture 6, Thursday, Feb 5. Hox and homeotic genes.
Lecture 7, Tuesday, Feb 10. Compartments and wing patterning. (lecture notes, engrailed, wing disks)
Lecture 8, Thursday, Feb 12. Evo-Devo.
Midterm I: Tuesday, February 17, 11:10-12:30Recommended Reading:
Chp 21, Moelcular Biology of the Gene, Watson et al. 7th Edition
Chapter 8, Essential Cell Biology, Alberts et al. 4th Edition
II. Professor John Gerhart
Middle third of the course: Early development of vertebrates from the oocyte to the late neurula stage.
Referenced Textbook (recommended, not required): Scott F. Gilbert, Developmental Biology, Ninth (2010) or Eighth Edition (2006)Lecture 1, Thursday, Feb 19. Chordates and vertebrates: defining traits, outline of amphibian development 6-11 (42-46; 216-217; 722; 725-731; 742-744)
Lecture 2, Tuesday, Feb 24. Fate, competence, specification, determination. Discovery of Spemann’s organizer. 19-21; 112-113; 241-244; 255-256 (10-13; 25-31; 57-62. 304-306)
Lecture 3, Thursday, Feb 26. Cytoplasmic localizations, cortical rotation, and axis formation in the amphibian egg 92-93; 242-244 (81-83; 136; 153-158; 615-619 and 291-294; 302-310).
Lecture 4, Tuesday, Mar 3. Endo-mesoderm induction 94-95; 257-262 (155-158; 311-312).
Lecture 5, Thursday, Mar 5. Formation of Spemann's organizer 261-263 (312-324).
Lecture 6, Tuesday, Mar 10. Gastrulation 9; 244-252 (29; 295-302).
Lecture 7, Thursday, Mar 12. Neural induction and neurulation 79-80; 263-272; 336 (312-324; 375-381).
Lecture 8, Tuesday, Mar 17. Chick development and extraembryonic development 287-297; 480-482 (336-348; 501-503; 45).
Lecture 9, Thursday, Mar 19. Mammalian early development 300-313 (92-96; 348-368).
Spring Break March 23-27
Lecture 1, Tuesday, Mar 31. Professor Richard Harland: Summary of amniote and mammalian gastrulation, overview of organogenesis – material not on Midterm 2
Midterm 2: Thursday, Apr 2, 11:10-12:30. (Note: Midterm 2 comes after Professor Harland’s Lecture 1 on April 2nd, but will not contain material from that lecture.)
III. Professor Richard Harland
Final third of the course: late development of vertebrates--organogenesis, cytodifferentiation. Lecture notes and reading assignments will be posted later.
(Lecture 1,Tuesday, Mar 31. Summary of amniote and mammalian gastrulation, Overview of organogenesis [see above])
(Midterm 2: Thursday, Apr 2 [see above])
Lecture 2, Tuesday, Apr 7. Embryonic signals and mesoderm induction.
Lecture 3, Thursday, Apr 9. Neural Tube: induction, morphogenesis, patterning, and differentiation.
Lecture 4, Tuesday, Apr 14. Neural Tube: cont'd.
Lecture 5, Thursday, Apr 16. Somite differentiation.
Lecture 6, Tuesday, Apr 21. Neural crest and placodes.
Lecture 7, Thursday, Apr 23. Muscle development.
Lecture 8, Tuesday, Apr 28. Limb development.
Lecture 9, Thursday, Apr 30.. Endodermal derivatives and kidney. Summary of organogenesisReading/Review/Recitation week May 4-8.
Final Exam: Final Exam Group 13 - Thursday, May 14, 2014, 8–11am, in 2040 VLSB (location may change, TBA).
Section 101
Mondays 2:00–3:00pm
250 Dwinelle
Section 102
Wednesday 1:00–2:00pm
2011 VLSB
Section 103
Wednesdays 8:00–9:00am
209 Dwinelle
Section 104
Fridays 12:00–1:00pm
2066 VLSB