FSH and LH

FSH and LH

FSH and LH in Females and Males

	FSH	LH
Female	stimulates ovary to produce steroids ovary will produce estradiol during follicular phase and progesterone during luteal phase surge at midcycle, with LH, triggers ovulation	stimulates ovary to produce steoroids surge at midcycle triggers ovulation remember, luteinizing hormone turns the follicle into the corpeus luteum by triggering ovulation
Male	stimulates Sertoli cells to produce androgen-binding protein (ABP), thereby stimulating spermatogenesis FSH also stimulates Sertoli cells to produce inhibin, which provides negative feedback to the anterior pituitary to decrease FSH secretion	stimulates Leydig cells to produce testosterone testosterone provides negative feedback to anterior pituitary and hypothalamus

In the female:

Estrogen:

Negative feedback:
- occurs during follicular phases when estrogen levels are still low.
Postive feedback:
- occurs at high concentrations near the end of the follicular phase, estrogen becomes a positive inducer of the anterior pituitary
- positive feedback triggers the anterior pituitary to release more FSH and LH
- more FSH and LH cause the ovary to produce more estrogen
- the ensuing LH surge is responsible for ovulation

Progesterone:

stimulate secretory and vascular activity of the endometrium, preparing for implantation of an embryo
secreted by the corpus luteum, after ovulation
when corpus luteum regresses, progresterone levels fall
- new vasculature in endometrium regresses and the tissue sloughs off.