Curriculum Vitae
Martin Lawrence Privalsky

Present Position:

Professor
Section of Microbiology
and Section of Molecular and Cellular Biology
Division of Biological Sciences
University of California at Davis

July 1, 1992 to present time

Summary of Research Interests: My general interest is in the mechanisms by which proliferation and differentiation is regulated in normal cells, and in the abnormal processes that occur in neoplasia. My specific goal is a better understanding of the actions of the nuclear hormone receptors in normal cells and in oncogenesis. Nuclear hormone receptors are a family of ligand-regulated transcription factors, and include the steroid, retinoid, and thyroid hormone receptors. These receptors directly modulate gene expression in response to hormones of extracellular origin, and play critical roles in metazoan homeostasis, differentiation, and reproduction. In addition, aberrant nuclear hormone receptors have been implicated as causal or contributory factors in a variety of human and non-human cancers. My research seeks to exploit these aberrant oncogenic receptors, both to better elucidate the actions of their normal counterparts, and to determine the molecular pathways that operate in neoplasia.

Previous Positions:

Associate Professor
Department of Microbiology
University of California at Davis

July 1988 to July 1992

Assistant Professor
Department of Bacteriology (former name of department)
University of California at Davis

April, l984 to June, l988

Assistant Research Virologist
University of California at Davis
Dr. J. Michael Bishop's Laboratory
Department of Microbiology and Immunology and
The George Hooper Foundation
University of California at San Francisco

June l983 to April l984

Research Scientist
Chiron Corporation
Emeryville, California 94608
January l983 to May l983

Education and Degrees:

Post-doctoral (1979-1983): J. Michael Bishop Laboratory
Department of Microbiology
University of California at San Francisco

Ph. D. (1974-1979): Department of Biochemistry
Edward E. Penhoet, thesis advisor
University of California at Berkeley

B. S. (1970-1974): Department of Biochemistry
State University of New York at Stony Brook

Research Experience:

April 1984 to present: Signal transduction and transcriptional regulation in normal and neoplastic cells. Understanding the roles of the erb A oncogene protein (thyroid hormone receptor), retinoic acid receptors, and related transcription factors in normal cells and in neoplastic transformation.

January 1983 to May 1983: Scientist with the Chiron Corporation, developing a recombinant DNA vaccine for hepatitis A.

October 1979 to December 1982 and June 1983 to April 1984: Researcher with Dr. J. Michael Bishop (U.C.S.F.), identifying and characterizing proteins involved in oncogenesis by avian erythroblastosis virus.

March 1975 to September 1979: Ph.D. thesis with Dr. Edward E. Penhoet (U.C. Berkeley), studying the synthesis and post-translational modification of influenza viral proteins.

January 1973 to May 1974: Undergraduate research project with Dr. Vincent P. Cirillo (S.U.N.Y. Stony Brook) investigating membrane transport in mycoplasma and in yeast.

Professional Service:

Served as a member, National Science Foundation Eukaryotic Genetics Study Panel (1989-1990), Ad hoc member, National Institutes of Health Molecular Biology Study Section (1992) and Virology Study Section (1994).

Ad hoc reviewer on USDA grants and N.I.H. site visit committees.

Member of the Editorial Board of Archives of Biochemistry and Biophysics. Served as an ad hoc reviewer for the journals Molecular and Cellular Biology, Science, Journal of Biological Chemistry, Journal of Cell Biology, Proceedings of the National Academy of Sciences USA, EMBO Journal, and Molecular Endocrinology, J. Clinical Investigation, Oncogene, Virology, Genes and Development.

Publications:

  1. Privalsky, M. L. and E. E. Penhoet. 1977. Phosphorylated protein component present in influenza virions. Journal of Virology. 24, 401-405.
  2. Privalsky, M. L. and E. E. Penhoet. 1978. Influenza virus proteins: identity, synthesis, and modification analyzed by two-dimensional gel electrophoresis. Proceedings of the National Academy of Sciences USA. 75, 3625-3629.
  3. Privalsky, M. L. and E. E. Penhoet. 1981. The structure and synthesis of influenza virus phosphoproteins. Journal of Biological Chemistry 256, 5368-5376.
  4. Privalsky, M. L. and J. M. Bishop. 1982. Proteins specified by avian erythroblastosis virus: coding region localization and identification of a previously undetected erb B polypeptide. Proceedings of the National Academy of Sciences USA, 79, 3958-3962.
  5. Bishop, J. M., T. Gonda, M. L. Privalsky, D. Sheiness, and B. Vennstrom. 1982. Avian retrovirus genes that cause leukemia. In Differentiation and Function of Hematopoietic Cell Surfaces. Alan R. Liss, Inc. New York. pp. 263-271.
  6. Privalsky, M. L., L. Sealy, B. Vennstrom, and J., M. Bishop. 1983. The molecular genetics of avian erythroblastosis virus. In: Gene expression in Normal and Transformed Cells. Edited by J. E. Celis and R. Bravo. Plenum Press Inc, New York. pp. 193-208.
  7. Privalsky, M. L., L. Sealy, J. M. Bishop, J. P. McGrath, and A. D. Levinson. 1983. The product of the avian erythroblastosis virus erb B locus is a glycoprotein. Cell 32, 1257-1267.
  8. Sealy, L., G. Moscovici, C. Moscovici, M. L. Privalsky, and J. M. Bishop. 1983. Site specific mutagenesis of avian erythroblastosis virus: erb B is required for oncogenicity. Virology 130, 155-178.
  9. Privalsky, M. L., R. Ralston, and J. M. Bishop. 1984. The membrane glycoprotein encoded by the retroviral oncogene v-erb B is structurally related to tyrosine-specific protein kinases. Proceedings of the National Academy of Sciences USA 81, 704-707.
  10. Privalsky, M. L. and J. M. Bishop. 1984. Subcellular localization of the v-erb B protein, the product of a transforming gene of avian erythroblastosis virus. Virology 135, 356-368.
  11. Schatzman, R. C., G. I. Evan, M. L. Privalsky, and J. M. Bishop. 1986. Orientation of the v-erb B gene product in the plasma membrane. Molecular and Cellular Biology 6, 1329-1333.
  12. Ng, M. and M. L. Privalsky. 1986. Structural domains of the avian erythroblastosis virus erb B protein required for fibroblast transformation: dissection by in-frame insertional mutagenesis. Journal of Virology 58, 542-553.
  13. Bassiri, M. and M. L. Privalsky. 1986. Mutagenesis of the avian erythroblastosis virus erb B coding region: an intact extracellular domain is not required for oncogenic transformation. Journal of Virology 59, 525-530.
  14. Privalsky, M. L. 1987. Creation of a chimeric oncogene: analysis of the biochemical and biological properties of a v-erb B/src fusion polypeptide. Journal of Virology 61, 1938-1948.
  15. Bassiri, M. and M. L. Privalsky. 1987. Transmembrane domain of the avian erythroblastosis virus erb B oncogene protein is not required for partial manifestation of the transformed phenotype. Virology 159, 20-30.
  16. Boucher, P., A. Koning, and M. L. Privalsky. 1988. The avian erythroblastosis virus erb A oncogene encodes a DNA-binding protein exhibiting distinct nuclear and cytoplasmic subcellular localizations. Journal of Virology 62, 534-544.
  17. Privalsky, M. L., P. Boucher, A. Koning, and C. Judelson. 1988. Genetic dissection of functional domains within the avian erythroblastosis virus v-erb A oncogene. Molecular and Cellular Biology 8, 4510-4517.
  18. Privalsky, M. L. 1990. A subpopulation of the avian erythroblastosis virus v-erb A protein, a member of the nuclear hormone receptor family, is glycosylated. Journal of Virology 64, 463-466.
  19. Bonde, B. G. and M. L. Privalsky. 1990. Sequence-specific DNA binding by the v-erb A protein. Journal of Virology 64, 1314-1320.
  20. Boucher, P. and M. L. Privalsky. 1990. Mapping of functional domains within the v-erb A oncogene protein: the remnants of the hormone binding domain play multiple vital roles in protein action. Oncogene 5, 1303-1311.
  21. Privalsky, M. L., M. Sharif, and K. R. Yamamoto. 1990. The viral erb A oncogene protein, a constitutive repressor in animal cells, is a hormone-regulated activator in yeast. Cell 63, 1277-1286.
  22. Privalsky, M. L. 1991 The v-erb A oncogene protein of avian erythroblastosis virus exists in a high molecular weight complex with heat shock protein-90. Journal of Biological Chemistry 266, 1456-1462.
  23. Bonde, B., M. Sharif, and M. L. Privalsky. 1991. Ontogeny of the v-erb A oncoprotein from the thyroid hormone receptor: an alteration in the DNA binding domain plays a role crucial for v-erb A function. Journal of Virology 65, 2037-2056.
  24. Sharif, M. and M. L. Privalsky. 1991. V-erb A oncogene function in neoplasia correlates with its ability to repress retinoic acid receptor action. Cell 66, 885-893.
  25. Sharif, M. and M. L. Privalsky. 1992. V-erb A and c-erb A proteins enhance transcriptional activation by c-jun. Oncogene 7, 953-960.
  26. Hall, B. L., B. G. Bonde, C. Judelson, and M. L. Privalsky. 1992. Functional interaction between the two zinc finger domains of the v-erb A oncoprotein. Cell Growth and Differentiation. 3, 207-216.
  27. Privalsky, M. L. 1992. Retinoid and thyroid hormone receptors: ligand-regulated transcription factors as protooncogenes. (An invited review). Seminars in Cell Biology. 3, 99-106.
  28. Privalsky, M. L. 1992. V-erb A, nuclear hormone receptors, and oncogenesis (An invited review). Biochimica et Biophysica Acta. 1114, 51-62.
  29. Smit-McBride, Z. and M. L. Privalsky. 1993. Functional domains of the v-erb A protein required for transcriptional activation in Saccharomyces cerevisiae. Oncogene 8, 1465-1475.
  30. Sande, S., M. Sharif, and M. L. Privalsky. 1993. V-erb A effects on retinoic acid receptors in immature avian erythroid cells suggest a mechanism of oncogene action. J. Virology 67, 1067-1074.
  31. Chen, H.-W., Z. S. McBride, S. Lewis, M. Sharif, and M. L. Privalsky. 1993. Nuclear hormone receptors involved in neoplasia: Erb A displays a novel DNA recognition specificity determined by amino acids outside of the "zinc-finger" domain. Mol. Cell. Biol. 13, 2366-2376 (1993).
  32. Chen, H.-W., and M. L. Privalsky. 1993. The erb A oncogene inhibits both RAR and RXR classes of retinoid receptors, but by different mechanisms. Mol. Cell. Biol. 13, 5970-5980.
  33. Hall, B., Z. Smit-McBride, and M. L. Privalsky. 1993. Reconstitution of RXR function, and combinatorial regulation of other nuclear hormone receptors, in the yeast Saccharomyces cerevisiae. Proc. Nat. Acad. Sci. USA. 90, 6929-6933.
  34. Schuh, T., B. L. Hall, J. C. Kraft, M. L. Privalsky, and D. Kimelman. 1993. V-erb A and citral reduce the teratogenic effects of all-trans retinoic acid and retinol, respectively, in Xenopus embryogenesis. Development 119, 785-798.
  35. Smit-McBride and M. L. Privalsky. 1994. DNA sequence specificity of the v-Erb A oncoprotein/thyroid hormone receptor: role of the P-box and its interaction with more N-terminal determinants of DNA recognition. Molecular Endocrinology 8, 819-828.
  36. Sande, S. and M. L. Privalsky. 1994. Reconstitution of retinoid and thyroid hormone receptor function in the fission yeast Schizosaccharomyces pombe permits elucidation of novel receptor actions. Molecular Endocrinology. 8, 1455-1462.
  37. Chen, H.W. and M. L. Privalsky. 1995. Cooperative formation of high order oligomers by retinoid X receptors: an unanticipated mode of DNA recognition. Proc. Natl. Acad. Sci. USA. 92, 422-426.
  38. Wong, C.-W. and M. L. Privalsky. 1995. Role of the N-terminus in DNA recognition by the v-erb A protein, an oncogenic derivative of a thyroid hormone receptor. Molecular Endocrinology, 9, 551-562.
  39. Judelson, C. and M. L. Privalsky. 1996. DNA recognition by normal and oncogenic thyroid hormone receptors. J. Biol. Chem. 271, 10800-10805.
  40. Sande, S. and M. L. Privalsky. 1996. Identification of TRACs, a family of cofactors that associate with, and modify the transcriptional properties of, nuclear hormone receptors. Molecular Endocrinology 10, 813-825.
  41. Yoh, S., V. K. K. Chatterjee, and M. L. Privalsky. 1997. Thyroid hormone resistance syndrome manifests as an aberrant interaction between mutant T3 receptors and transcriptional corepressors. Molecular Endocrinology 11, 470-480.
  42. Lin, B. C., C.-W. Wong, H.-W. Chen, and M. L. Privalsky. 1997. Plasticity of tetramer formation by retinoid X receptors, an alternative paradigm for DNA recognition. J. Biol. Chem. 272, 9860-9867.
  43. Chen, H.-W. and M. L. Privalsky. 1997. Retinoid X and retinoic acid receptors interact with TFIIB by distinct mechanisms. Mol. Cell. Endocrinology 129, 55-61.
  44. Hong, S.-H., G. David, C.-W. Wong, A. Dejean, and M. L. Privalsky. 1997. SMRT corepressor interacts with PLZF, and with the PML-RARa and PLZF-RARa oncoproteins associated with acute promyelocytic leukemia. Proc. Natl. Acad. Sci. USA 94, 9028-9033.
  45. Lin, B. C., S.-H. Hong, S. Krig, S. M. Yoh, and M. L. Privalsky. 1997. A conformational switch in the nuclear hormone receptors is involved in coupling hormone binding to corepressor release). Mol. Cell. Biol. 17, 6131-6138.
  46. Chen, H.-W., R. J. Lin, D. Chakravarti, L. Schiltz, A. Nash, L. Nagy, M. L. Privalsky, Y. Nakatani, and R. M. Evans. 1997. Nuclear receptor co-activator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90, 569-580.
  47. Tzagarakis, C. and M. L. Privalsky. Phosphorylation by protein kinase A alters the DNA recognition properties of the thyroid hormone receptor and the v-Erb A oncoprotein (Submitted to J Biol Chem).

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