Curriculum Vitae
Edward E. Penhoet

Ed Penhoet


Edward E. Penhoet, Ph.D., is President and Chief Executive Officer of Chiron, a biotechnology company headquartered in Emeryville, California, near San Francisco. Dr. Penhoet, 56, has been CEO since co-founding the company in 1981. Dr. Penhoet has responsibility for Chiron Therapeutics, as well as finance and administration, regulatory and quality affairs, manufacturing, engineering, human resources and its relationships with the financial community and other key publics.

Dr. Penhoet earned his A.B. in biology from Stanford University in 1963, and his Ph.D. in biochemistry from the University of Washington in 1968. He was a post-doctoral fellow at the University of California, San Diego, from 1968 to 1970.

For 10 years prior to founding Chiron, Dr. Penhoet was a faculty member of the Biochemistry Department of the University of California, Berkeley, and continues as an adjunct member of the faculty, teaching each year. In May 1991, Dr. Penhoet received the first Distinguished Faculty Award from the Life Sciences Department of Molecular and Cell Biology at the University of California, Berkeley. In 1992, Dr. Penhoet shared with Dr. William J. Rutter, a Chiron co-founder, the Northern California Entrepreneur of the Year Award presented by Ernst & Young and Inc. Magazine; in 1994, they received jointly the Harvard Business School Northern California Alumni Chapter award as Entrepreneur of the Year.

Dr. Penhoet is Chairman of the California Health Care Institute, Oakland Museum Foundation, and a member of the National Research Council. He is a member of the Boards of Directors of the California Business Higher Education Forum, Biotechnology Industry Organization, the Bay Area BioScience Center, the Bay Area Council, the California Public Health Foundation, the Chabot Observatory and Science Center Foundation, the UC System Biotech Advisory Committee, , Onyx Pharmaceuticals, the UC Berkeley ChancellorÕs Biotechnology Planning Board and the Advisory Board for the Lester Center for Entrepreneurship and Innovation at UC Berkeley. He is a member of the American Society of Biological Chemists, and has published more than 50 scientific articles and papers.

Dr. Penhoet is married with two grown children and lives with his wife in his hometown of Oakland, California.


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PUBLICATIONS

l. Rajkuman, T.V., Penhoet, E.E., and Rutter, W.J. Subunits and Multiple Forms of Fructose Diphosphate Aldolases, Federation Proceedings, 25, 523 (1966).

2. Penhoet, E.E., Rajkumar, T.V., and Rutter, W.J. Multiple Forms of Fructose Diphosphate Aldolase in Mammalian Tissues, Proceedings of the National Academy of Sciences, 56, 1275 (1966).

3. Rutter, W.J., Rajkumar, T.V., Penhoet, E.E., Koshman, M., and Valentine, R. Aldolase Variants: Structure and Physiological Significance, The Annals New York Academy of Science, 151, 102 (1968).

4. Penhoet, E.E., Kochman, M., Valentine, R., and Rutter, W.J. The Subunit Structure of Mammalian Fructose Diphosphate Aldolase, Biochemistry 6, 2940 (1967).

5. Kochman, M., Penhoet, E.E., and Rutter, W.J. Characterization of the Subunits of Aldolases A and C, Federation Proceedings, 27, 690 (1968).

6. Penhoet, E.E. Ph.D. Thesis: The Structure, Function, and Distribution of Mammalian Fructose Diphosphate Aldolases, University of Washington (1968).

7. Penhoet, E.E., Kochman, M., and Rutter, W.J. Isolation of Fructose Diphosphate Aldolases A,B, and C, Biochemistry 8, (11) 4391 (1969).

8. Penhoet, E.E., Kochman, M., and Rutter, W.J. Molecular and Catalytic Properties of Aldolase C, Biochemistry 8, 4396 (1969).

9. Penhoet, E.E., and Rutter, W.J. Catalytic and Immunochemical Properties of Homomeric and Heterometic Combinations of Aldolase Subunits,Journal of Biological Chemistry 246, 318 (1971).

10. Etchison, J. Doyle, M., Penhoet,E.E., and Holland, J.J. Synthesis and Cleavage of Influenza Virus Proteins, Journal of Virology 7, 155 (1971).

11. Penhoet, E. E., Miller, H., Doyle, M., and Blatti, S.M. RNA Dependent RNA Polymerase Activity in Influenza Virions, Proceedings of the National Academy of Sciences 68, 1369 (1971).

12. Penhoet, E.E., and Holland, J.J. Transfer RNA Species in Solid Human Tumors, Journal of the National Cancer Institute 47, 1173 (1971).

13. Miller, H.I., and Penhoet, E.E. Differential Inhibition of Nuclear RNA Polymerases in L Cells Infected with Mengovirus, Proceedings of the Society for Experimental Biology and Medicine 140, 435 (1972).

14. Penhoet, E.E. Analysis of Specific Proteins in Differentiating Tissues in M. Chrispeels, ed. Molecular Techniques in Developmental Biology, J. Wiley and Sons (1973).

15. Olsen, C.E., and Penhoet, E.E. Comparison of Tyrosyl T-RNAs from Mammalian Sources, Federation Proceedings 33, 1279 (1974).

l6. Apriletti, J., and Penhoet, E.E. Recovery of DNA-dependent RNA Polymerase Activities from Mengovirus Infected L Cells, Virology 61, 597 (1974).

17. Longo, A.M., and Penhoet, E.E. Nerve Growth Factor in Rat Glioma Cells, Proceedings of the National Academy of Sciences 71, 2347 (1974).

18. Penhoet, E.E., Olsen, C.E., Carlson, S., Lacorbiere, M., and Nicholson, G.L. Quantitive Interaction of "Ricinus Communis" Agglutinin and Concanavalin A with Influenza and Vesicular Stomatitis Viruses and Virus-Infected Normal and Polyoma-Transformed Cells, Biochemistry 13, 3561 (1974).

19. Longo, A.M., and Penhoet, E.E. Nerve Growth Factor in Rat Glioblastoma Cells, Federation Proceedings 33, 1409 (1974).

20. Penhoet, E.E., and Rutter, W.J. Detection and Isolation of Mammalian Fructose Diphosphate Aldolases, Methods in Enzymology 42, 240 (1975).

21. Susor, W.A., Penhoet, E.E., and Rutter, W.J. Fructose Diphosphate Aldolase, Pyruvate Kinase, and Pyridine-Nucleotide-Linked Activities after Electrophoresis, Methods in Enzymology 41, 66 (1975).

22. Mullenbach, G.T., Kammen, H.O., and Penhoet, E.E. A Heterologous System for Detecting Eukaryotic Enzymes Which Synthesize Pseudouridine in Transfer Ribonucleic Acids, J. Biol. Chem. 251, 4570 (1976).

23. Kuhnlein, U., Penhoet, E.E., and Linn, S.M. An Altered Apurinic DNA Endonuclease Activity in Xeroderma Pigmentosum Fibroblasts. Proc. Nat`l Acad. Sci. 73, 1169 (1976).

24. Tekamp, P., and Penhoet, E.E. On the Message Activity of Influenza Viral RNA. J. Virol. 18, 812-816 (1976).
25. Colby, C., Penhoet, E.E., and Summuel, C.E. A Comparison of Transfer RNAs From Untreated and Interferon Treated Murine Cells. Virology I74, 262 (1976).

26. Olsen, C.E., and Penhoet, E.E. Chromatographic and Functional Comparison of Human Placenta and HeLa Cell Tyrosine Transfer Ribonucleic Acids. Biochemistry 15, 4649 (1976).

27. Linsley, S.W., Penhoet, E.E., and Linn, S.M. Human Endonuclease Specific for Apurinic/Apyrimidic Sites in DNA. J. Biol. Chem. 252, 1235 (1977).

28. Privalsky, M., and Penhoet, E.E. Phosphorylated Protein Component Present in Influenza Virions. J. Virol. 24, 201 (1977).

29. Apriletti, J.A., and Penhoet, E.E. Cellular RNA Synthesis in Normal and Mengo-virus-infected L-929 Cells. J. Biol. Chem. 253, 603 (1978).

30. Kuhnlein, U., Lee, B., Penhoet, E.E., and Linn, S.M. Xeroderma Pigmentosum Fibroblasts of the D Group Lack an Apurinic DNA Endonuclease Species with a Low Apparent K_. Nuc. Res. 5, (3), 951 (1978).

31. Privalsky, M., and Penhoet, E.E. Influenza Virus Proteins: Identity Synthesis, and Modification Analyzed by Two Dimensional Gel Electrophoresis. Proc. Nat. Acad. Sci. 75, 3625-3629 (1978).

32. Dina, D., and Penhoet, E.E. Viral Gene Expression in MSV(MLV) Infected Cells. J. Virol. 27, 768-775 (1978).

33. Reading, C.R., Penhoet, E.E., and Ballou, C.E. Carbohydrate Structure of Vesticular Stomatitis Virus Glycoprotein. J. Biol. Chem. 253, 5600-5612 (1978).

34. Longo, A.M., and Penhoet, E.E. Synthesis of Nerve Growth Factor in Rat Glioma Cells. Developmental Biology 65, 260 (1978).

35. Dina, D., and Penhoet, E.E. The "Sarcoma Specific" Region of Moloney Murine Sarcoma Virus 124. Proc. Nat. Acad. Sci. 75, 2694-2698 (1978).

36. Kudrna, R., Smith, J., Linn, S.M., and Penhoet, E.E. Survival of Apurinic SV40 DNA in the D-Complementation Group of Xeroderma Pigmentosum. Mutation Res. 62, 173-181 (1979).

37. Tekamp, P., and Penhoet, E.E. Quantification of Influenza Virus Messenger RNAs. J. Gen. Virol. 47, 449 (1980).

38. Maack, C.A, and Penhoet, E.E. Biochemical Characterization of the ts E-1 Mutant of Vesicular Stomatitis Virus (New Jersey). J. Biol. Chem. 255 (19), 9249-9254 (1980).

39. Privalsky, M. and Penhoet, E.E. The Structure and Synthesis of Influenza Virus Phosphoproteins. J. Biol. Chem. 256, 5368-5376 (1981).

40. Green, C.J., Kammen, H.O., and Penhoet, E.E. Purification and Properties of a Mammalian tRNA Pseudouridine Synthase. J. Biol. Chem. 257, 3045-3052 (1982).

4l. Jacobs, B.L. and Penhoet, E.E. Assembly of Vesicular Stomatitis Virus: Distribution of the Glycoprotein on the surface of infected cells. J. Virol. 44, l047-l055 (1982).

42. Tolan, D., Amsden, A.B., Putney, S.D., Urea, M.S. and Penhoet, E.E. The Complete Nucleotide Sequence for Rabbit Muscle Aldolase Messenger RNA. J. Biol. Chem. 259, ll27-ll3l (1983).

43. Rottmann, W.H., Tolan, D.R. and Penhoet, E.E. Complete Amino Acid Sequence for Human Aldolase B Derived from cDNA and Genomic Clones. Proc. Natl. Acad. Sci. USA 8l, 2738-2743 (1984).

44. Marvel, C.C., Arps, P.J., Rubin, B.C., Kammen, H.O. and Penhoet, E.E. His T is Part of a Multigene Operon in Escherichia coli K-l2. J. Bact. l6l, 60-7l (1985).

45. Burgess, D.G. and Penhoet, E.E. Characterization of the Chicken Aldolase B Gene. J. Biol. Chem. 260, 4604-46l4 (1985).

46. Arps, P.J., Marvel, C.C., Rubin, B.C., Tolan, D.R., Penhoet, E.E. and Winkler, M.E. Structural Featurs of the His T Operon of Escherichia coli K-l2. Nucl. Acids Res. l3, 5297-53l5 (1985).

47. Tolan, D.R. and Penhoet, E.E. Characterization of the Human Aldolase B Gene. Molecular Biology and Medicine, 3, 24-264 (1986).

48. Kelley, P.M. and Tolan, D.R. The Complete Amino Acid Sequence for the Anaerobically Induced Aldolase from Maize Derived from cDNA Clones. Plant Phys. 82, l076-l080 (1986).

49. Rottmann, W.H., DeSelms, K.R., Niclas, J., Camerato, T., Holman, P.S., Green, C.J. and Tolan, D.R. The Complete Amino Acid Sequence of the Human Aldolase C Isozyme Derived from Genomic Clones. Biochimie, 69, l37-l45 (1987).

50. Nonet, M.L., Marvel, C.C. and Tolan, D.R. The hisT-purF Region of the Escherichia coli K-l2 Chromosome: Identification of additional genes of the hisT and purF operons. J. Biol. Chem. 262, l2209-l22l7 (1987).

5l. Tolan, D.R., Niclas, J., Bruce, B.D. and Lebo, R.V. Evolutionary Implication of the Human Aldolase A, B, C and Pseudo-gene Chromosomal Locations. American Journal of Human Genetics 4l, 907-924 (1987).

52. Kammen, H.O., Marvel, C.C., Hardy, L. and Penhoet, E.E. Purification, Structure, and Properties of Escherichia coli tRNA Pseudouridine Synthase I. J. Biol. Chem. 263, 2255-2263 (1988)

53. Amsden, A.B., Penhoet, E.E. and Tolan, D.R. A Rabbit AldA Pseudogene Derived from a Partially Spliced Primary Aldolase A Transcript. Gene 120, 323-324 (1992).

54. Penhoet, E.E. The Future of U.S. Science Policy. ASM News, Vol. 59, No. 1, 6-7 (1993).

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