Date of birth: 19 September 1943
Place of birth: Oxford, England
Citizenship: U.S.
1961-1964 Foundation Scholar, Queens' College, Cambridge; B.A. (Biochemistry) 1964
1964-1968 Graduate student, MRC Laboratory of Molecular Biology, Cambridge, with Dr. S. Brenner; Ph.D. 1968
1968-1971 Postdoctoral Fellow, Virus Laboratory, University of California, Berkeley, with Dr. H. Rubin
1971-1975 Staff member, Imperial Cancer Research Fund, London
1975-1979 Assistant Professor, Department of Zoology, and Assistant Research Virologist, Cancer Research Laboratory, University of California, Berkeley
1979-1983 Associate Professor, Department of Zoology, and Associate Research Virologist, Cancer Research Laboratory, University of California, Berkeley
1983-1989 Professor, Department of Zoology, and Research Virologist, Cancer Research Laboratory, University of California, Berkeley
1989-present Professor, Department of Molecular and Cell Biology, and Research Virologist, Cancer Research Laboratory, University of California, Berkeley
1973-1985 Associate Editor, BBA Reviews on Cancer
1976-1977 Special Grants Committee, American Cancer Society (California Division)
1977-1979 Postdoctoral Fellowships Committee, American Cancer Society (California Division)
1981 Member, Committee on Retrovirus Transforming Genes, Retrovirus Study Group, International Committee on Taxonomy of Viruses
1983-1987 Scientific Advisory Committee, Damon Runyon-Walter Winchell Cancer Fund
1984 Co-organizer, Cold Spring Harbor RNA Tumor Virus Meeting
1988-1993 Cancer Research Coordinating Committee, University of California
1992-present Associate Editor, Virology
1968-1970 Jane Coffin Childs Memorial Fund Fellowship
1970-1971 American Cancer Society Dernham Fellowship
1989-present National Institutes of Health, Merit Award
1991-1992 John Simon Guggenheim Memorial Foundation Fellowship
1991-1992 American Cancer Society Scholar Award in Cancer Research
Societies American Association for the Advancement of Science
American Society for Microbiology
American Society for Cell Biology
Current research grant support
1975-present National Institutes of Health Grant CA17542, "Genetics of RNA Tumor Viruses" Merit Award
Wilson, L.K., Dhillon, N., Thorner, J. and Martin, G.S. Casein kinase II catalyzes tyrosine phosphorylation of the yeast nucleolar immunophilin Fpr3. J. Biol. Chem. 272, 12961-12967 (1997).
Trager, J.B. and Martin, G.S. The role of the Src homology-2 domain in the lethal effect of Src expression in the yeast Saccharomyces cerevisiae. Int. J. Biochem. Cell Biol. 29, 635-648 (1997).
Tian, M. and Martin, G.S. The role of the Src homology domains in morphological transformation by v-src. Mol. Biol. Cell. 8, 1183-1193 (1997).
Brazill, D.T., Thorner, J.W. and Martin, G. S. Mck1, a member of the glycogen synthase kinase-3 family of protein kinases, is a negative regulator of pyruvate kinase in the yeast Saccharomyces cerevisiae. Journal of Bacteriology 179, 4415-4418 (1997).
Huang, L., Weng, X., Hofer, F., Martin, G.S. and Kim, S.-H. Three-dimensional structure of the Ras interacting domain of RalGDS, a guanine nucleotide dissociation stimulator of the Ral protein. Nature Structural Biology 4, 609-615 (1997).
Aftab, D., Kwan, J., and Martin, G.S. Ras-independent transformation by v-Src. Proc. Natl. Acad. Sci. USA. 94, 3028-3033 (1997).
Huang, L., Jancarik, J, Kim, S.-H., Hofer, F. and Martin, G.S. Crystallization and preliminary crystallographic analysis of the Ras binding domain of RalGDS, a guanine nucleotide dissociation stimulator of the Ral protein. Acta Crystallographica D52, 1033-1035 (1996).
Tian, M. and Martin, G.S. Reduced phosphotyrosine binding by the v-Src SH2 domain is compatible with wild-type transformation. Oncogene 12, 727-734 (1996).
Wilson, L., Benton, B., Zhou, S., Thorner, J. and Martin, G.S. The Yeast Immunophilin Fpr3 is a Physiological Substrate of the Tyrosine-specific Protein Phosphatase Ptp1. J. Biol. Chem. 270, 25185-25193 (1995).
Jiang, W., Lim, M.-L., Yoon, Y.-J., Thorner, J., Martin, G.S. and Carbon, J. Overexpression of the yeast MCK1 protein kinase supresses conditional mutations in centromere-binding protein genes CBF2 and CBF5. Mol. Gen. Genet. 246, 360-366 (1995).
Hofer, F., Fields, S., Schneider, J.C. and Martin, G.S. Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator. Proc. Natl. Acad. Sci. USA. 91, 11089-11093 (1994).
Florio, M., Wilson, L., Trager, J., Thorner, J. and Martin, G.S. Aberrant protein phosphorylation at tyrosine is responsible for the growth-inhibitory action of pp60v-src expressed in the yeast Saccharomyces cerevisiae. Molecular Biology of the Cell 5, 283-296 (1994).
Lim, M.-Y., Dailey, D., Thorner, J. and Martin, G.S. Yeast MCKI protein kinase autophosphorylates at tyrosine and serine but phosphorylates exogenous substrates at serine and threonine. J. Biol. Chem. 268, 21155-21164 (1993).
Kelly, T.J., Martin, G.S., Forsburg, S.L., Stephen, R.J., Russo, A. and Nurse, P. The fission yeast cdc18+ gene product couples S-phase to Start and mitosis. Cell 74, 371-382 (1993).
Liebl, E., England, L.J. and Martin, G.S. Reactivation of host-dependent src kinase activity by co-expression with a heterologous tyrosine kinase. Virology 195, 265-267 (1993).
Liebl, E.C. and Martin, G.S. Intracellular targeting of pp60src expression: localization of v-src to adhesion plaques is sufficient to transform chicken embryo fibroblasts. Oncogene 7, 2417-2428 (1992).
Liebl, E.C., England, L., DeClue, J.E. and Martin, G.S. Host range mutants of v-src: alterations in kinase activity and substrate interactions. J. Virol. 66, 4315-4324 (1992).
Foster, R. and Martin, G.S. A mutation in the catalytic domain of pp60v-src is responsible for the host- and temperature-dependent phenotype of the Rous sarcoma virus mutant tsLA33-1. Virol. 187, 145-155 (1992).
Ferrell, J.E, Jr. and Martin, G.S. Assessing activities of blotted protein kinases. Methods Enzymol. 200, 430-435 (1991).
Ferrell, J., Wu, M., Gerhart, J. and Martin, G.S. Cell cycle tyrosine phosphorylation of p34cdc2 and a MAP-kinase homolog in Xenopus oocytes and eggs. Mol. Cell Biol. 11, 1965-1971 (1991).
Moran, M.F., Koch, C.A., Anderson, D., Ellis, C., England, L., Martin, G.S. and Pawson, T. Src homology region 2 domains direct protein-protein interactions in signal transduction. Proc. Natl. Acad. Sci. USA. 87, 8622-8626 (1990).
Ferrell, J. and Martin, G.S. Identification of a 42-kDa phosphotyrosyl-protein as a serine/threonine-specific protein kinase by renaturation. Mol. Cell. Biol. 10, 3020-3026 (1990).
Ferrell, J.E. Jr., Nobel, J.A., Martin, G.S., Jacques, Y.V. and Bainton, D.F. Intracellular localization of pp60c-src in human platelets. Oncogene, 5, 1033-1036 (1990).
Dailey, D., Schieven, G., Lim, M.-Y., Marquardt, H., Gilmore, T., Thorner, J., and Martin, G.S. Novel yeast protein kinase (YPK1 gene product) is a 40-kilodalton phosphotyrosyl-protein associated with protein-tyrosine kinase activity. Mol. Cell. Biol. 10, 6244-6256 (1990).
Foster, R., Thorner, J., and Martin, G.S. Nucleotidylation, not phosphorylation, is the major source of the phosphotyrosine detected in enteric bacteria. J. Bact. 171, 272-279 (1989).
DeClue, J. and Martin, G.S. Linker insertion/deletion mutagenesis of the v-src gene: isolation of host- and temperature-dependent mutants. J. Virol. 63, 542-554 (1989).
Ferrell, J. and Martin, G.S. Tyrosine-specific protein phosphorylation is regulated by glycoprotein IIb-IIIa in platelets. Proc. Natl. Acad. Sci. USA 86, 2234-2238 (1989).
Ferrell, J. and Martin, G.S. Thrombin stimulates the activities of multiple previously unidentified protein kinases in platelets. J. Biol. Chem. 264, 20723-20729 (1989).