Curriculum Vitae
Paul A. Luciw, Ph.D.

Present position: Associate Professor
Department of Pathology, 3444 Tupper Hall
School of Medicine
University of California
Davis, CA 95616

Tel: 916-752-3430
Fax: 916-752-4548
E-mail: PALuciw@UCDavis.edu

Education and Professional Experience:

Cornell University, College of Arts and Sciences, Ithaca, NY

University of Pennsylvania, Graduate School of Arts and Sciences, Philadelphia, PA

Thesis dissertation - Assembly of Adenovirus Type 5

(thesis advisor - Dr. Harry S. Ginsberg)

Post-doctoral fellow - 1978 to 1982, Department of Microbiology (mentors - Drs. J. Michael Bishop and Harold E. Varmus), University of California, San Francisco, CA

Scientist - 1982 to 1984, Principal Scientist - 1984 to 1985, and Senior Scientist - 1985 to 1986,

Chiron Corporation, Emeryville, CA

Assistant Adjunct Professor - 1986 to 1990, Associate Adjunct Professor - 1990 to 1991; Department of Pathology, School of Medicine, University of California, Davis, CA

Associate Professor in Residence - 1992 to 1994; Department of Pathology, School of Medicine, University of California, Davis, CA

Associate Professor - 1994 to present; Department of Pathology, School of Medicine, University of California, Davis, CA

Research Director, Viral Oncology Program - 1997 to present - University of California, Davis

Research Affiliate - 1986 to present; California Regional Primate Research Center, Davis, CA

Research Interests:

Research Laboratory

Department of Medical Pathology

University of California, Davis CA

Dr. Paul Luciw has extensive experience in many aspects of virology, cell biology, and molecular biology. The main emphasis of his research is on elucidating basic molecular mechanisms that regulate replication of simian immunodeficiency virus (SIV). A major aim of this research is to identify viral determinants of latency, persistence, and pathogenesis in non-human primate model systems (i.e., rhesus monkeys). Goals of this research are to identify functional domains on viral proteins and to identify cellular proteins interacting with these functional domains. An important component of Dr. Luciw's research involves the testing and development of recombinant anti-viral vaccines in the SIV/monkey and feline immunodeficiency virus (FIV)/cat model systems; these studies are directly relevant for the development of vaccines against the human immunodeficiency virus (HIV). Genetic engineering methods are also being used to design SIV vectors expressing cytokine genes; such viral vectors will be tested in rhesus monkeys for pathogenesis or attenuation. Through collaborative studies, Dr. LuciwÕs laboratory is testing the novel method of DNA immunization in rhesus monkeys inoculated with plasmid vectors expressing SIV antigens. Goals of this research are to elucidate molecular and cellular mechanisms that account for induction of anti-viral immune responses after DNA immunization.

Dr. Luciw's research group currently consists of the following individuals:

Research associates

Dr. Peter Barry (Ph.D., assistant research professor) - molecular pathogenesis of rhesus CMV

Dr. Earl Sawai (Ph.D., assistant adjunct professor) - signal transduction mediated by the HIV-1 and SIV nef genes

Post-doctoral fellows

Dr. Sunee Himathongkham (D.V.M., Ph.D.) - cell tropism of SIV/HIV-1 recombinants in macaques

Dr. Richard Reyes (D.V.M., Ph.D.) - molecular pathogenesis of SIV/HIV-1 recombinants

Dr. Elise Keddie (D.V.M.) - novel molecular clones of FIV for immunization

Graduate students

Mr. Joseph Oh - SIV and HIV-1 vectors for cytokine expression in macaques

Ms. Jinling Li - functional domains of HIV-1 env analyzed in macaques

Research assistants

Ms. Karen Shaw - staff research associate III - molecular cloning, DNA sequencing, expression vectors, protein purification, tissue culture, virology, laboratory management

Ms. Kim Schmidt - staff research associate II - tissue culture, virology, laboratory management

Ms. Claudia Jo Weber - staff research associate II - tissue culture, virology

Mr. Michael Stout - staff research associate I - molecular cloning, DNA sequencing, synthesis of oligonucleotides

Journal Review Boards:

AIDS Research and Human Retroviruses - 1987 to present.

Virology - 1990 to present.

Committees and advisory boards:

Center for Comparative Medicine, U. C. Davis; founding member, 1993 to present.

Universitywide AIDS Research Program, State of California; member, 1992 - 1995.

U. C. Davis Biotechnology Advisory Board; member, 1992 to present.

The Chronic Fatigue Immune Dysfunction Syndrome (CFIDS) Association of America, Charlotte, NC; scientific advisory board, 1993 to present.

Basic Sciences Council, School of Medicine, U.C. Davis; charter member, 1996 to present.

Optical Biology Executive Committee, U.C. Davis; charter member, 1996 to present.

Targeted Action Group for Vaccines - AIDS Virus Research Institute, U.C. San Francisco, Sept. 97 to present.

Graduate groups at U. C. Davis:

Genetics - 1986 to present

Immunology - 1986 to present

Microbiology - 1986 to present

Biochemistry - 1990 to present

Comparative Pathology - 1992 to present

Course lecturer (instructor of record, 1990 to present):

Microbiology 262 - General Molecular Virology (J. Manning, P. Luciw, G. Bruening)

Patents (United States):

4,876,089 - Inventors: P. A. Luciw, D. L. Parkes, and G. A. Van Nest (Oct. 24, 1989) Feline Leukemia Virus Protein Vaccines. Assignee: Chiron Corporation (Emeryville, CA).

5,152,982 - Inventors: D. Parkes, P. Luciw, V. Van Nest, and D. Dina (Oct. 6, 1992) Compositions and Methods for FeLV Vaccination. Assignee: Chiron Corporation (Emeryville, CA).

5,156,949 - Inventors: P. A. Luciw and D. Dina (Oct. 20, 1992) Immunoassays for Antibody to Human Immunodeficiency Virus Using Recombinant Antigens. Assignee: Chiron Corporation (Emeryville, CA).

ACTIVE GRANTS FOR RESEARCH SUPPORT

1. NIH-NIAID, RO1-AI41907

SHIV Adaptation and Pathogenesis in Macaques

08-01-97 to 07-31-01

20% effort

2. NIH-NCRR, RR00169

California Regional Primate Research Center Base Grant

Subproject: Natural History of Rhesus Cytomegalovirus

05-01-95 to 04-30-2000

3. NIH-NIAID, RO1-AI38532

In vitro and In vivo Function of HIV and SIV Nef Genes

08-01-95 to 07-30-99

4. Univeristy of California AIDS Research Program. R96-D-166

Studies of HIV-1 Subtype-A Env Gene via SHIV Recombinants

07-01-96 to 06-31-98

5. NIH-NIAID, R21-AI42608

Cytokine Adjuvants for Genetic Immunization

10-01-97 to 09-31-99

PUBLICATIONS

Peer-review publications:

  1. DeLorbe, W.J., P.A. Luciw, H.M. Goodman, H.E. Varmus, and J.M. Bishop (1980) Molecular cloning and characterization of avian sarcoma virus circular DNA molecules. J. Virol. 36:50-61.
  2. Luciw, P.A., J.M. Bishop, H.E. Varmus, and M. R. Capecchi (1983) Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA. Cell 33:705.
  3. Luciw, P.A., H. Oppermann, J.M. Bishop, and H.E. Varmus (1983) Integration and expression of several molecular forms of Rous sarcoma virus DNA used for transfection of mouse cells. Mol. Cell Biol. 4:1260.
  4. Vennstrom, B., P. Kahn, B. Adkins, P. Enrietto, M.J. Hayman, T. Graf, and P.A. Luciw (1984) Transformation of mammalian fibroblasts and macrophages in vitro by a murine retrovirus encoding an avian v-myc oncogene. EMBO J. 3:3223-3229.
  5. Luciw, P.A., S.J. Potter, K. Steimer, D. Dina, and J.A. Levy (1984) Molecular cloning of AIDS-associated retrovirus. Nature 312:760.
  6. Sanchez-Pescador, R., M.D. Power, P. J. Barr, K.S. Steimer, M.M. Stempien, S.L. Brown-Shimer, W.W. Gee, A. Renard, A. Randolph, J.A. Levy, D. Dina, and P.A. Luciw (1985) Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2) Science 227:484-492.
  7. Bryant, M.L., J. Yamamoto, P. Luciw, R. Munn, P. Marx, J. Higgins, N. Pedersen, A. Levine, and M.B. Gardner (1985) Molecular comparison of retroviruses associated with human and simian AIDS. Hematological Oncology 3:187.
  8. Levy, J.A., L.S. Kaminsky, W.J.W. Morrow, K. Steimer, P. Luciw, D. Dina, J. Hoxie, and L. Oshiro (1985) Infection by the retrovirus associated with the acquired immunodeficiency syndrome. Clinical, biological, and molecular features. Ann. Int. Med. 103:694-699.
  9. Levy, J.A., C. Cheng-Mayer, D. Dina, and P.A. Luciw (1986) Replication of AIDS-associated retrovirus (ARV-2) in human and animal fibroblast cells transfected with a molecular clone of the virus. Science 232:998-1001.
  10. Jones, K.A., J.T. Kadonaga, P.A. Luciw, and R. Tjian (1986) Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1. Science 232:755.
  11. Power, M.D., P.A. Marx, M.S. Bryant, M.B. Gardner, P.J. Barr, and P.A. Luciw (1986) Nucleotide sequence of SRV-1, a type D simian acquired immunodeficiency retrovirus. Science 231:1567-1572.
  12. Peterlin, B.M., P.A. Luciw, P.J. Barr, and M.D. Walker (1986) Elevated levels of RNA can account for the transactivation of human immunodeficiency virus (HIV). Proc. Natl. Acad. Sci. USA 83:9734-9738.
  13. Delli Bovi, P., E. Donti, D. M. Knowles, A. Friedman-Kien, P. A. Luciw, D. Dina, R. Della-Favera, and C. Basilico (1986) Presence of chromosomal abnormalities and lack of AIDS retrovirus DNA sequences in AIDS-associated Kaposi's sarcoma. Cancer Research 46: 6333-6338.
  14. Pelicci, P.G., D.M. Knowles, A.Z. Arlin, R. Wieczorek, P. Luciw, D. Dina, C. Basilico, and R. Dalla-Favera (1986) Multiple monoclonal B-cell expansions and c-myc oncogene rearrangements in acquired immunodeficiency syndrome-related lymphoproliferative disorders. J. Exp. Med. 164:2049-2060.
  15. Steimer, K.S., K.W. Higgins, M.A. Powers, J.C. Stephans, A. Geynes, C. George-Nascimento, P.A. Luciw, P.J. Barr, R.A. Hallewell, and R. Sanchez-Pescador (1986) Recombinant polypeptide from the endonuclease region of the acquired immunodeficiency syndrome retrovirus polymerase (pol) gene detects serum antibodies in most infected individuals. J. Virol. 58:9-26.

Peer-review publications (continued):

16. Steimer, K.S., J.P. Puma, M.D. Power, M.A. Powers, C. George-Nascimento, J.C. Stephans, J.A. Levy, R. Sanchez-Pescador, P.A. Luciw, P.J. Barr, and R.A. Hallewell (1986) Differential antibody responses of individuals infected with AIDS-associated retroviruses surveyed using the viral core antigen p25gag expressed in bacteria. Virology 150:283-291.

17. Thayer, R.M., M.D. Power, M.L. Bryant, M.B. Gardner, P.J. Barr, and P.A. Luciw (1987) Sequence relationships of type D retroviruses which cause simian acquired immunodeficiency virus syndrome. Virology 157:317-329.

18. Rando, R.F., P. Pellet, P. A. Luciw, and A. Srinivasan (1987) Transactivations of human immunodeficiency virus by herpes viruses. Oncogene 1:12-18.

19. Srinivasan, A., R. Anand, D. York, P. Ranganathan, P. Feorino, G. Schochetman, J. Curran, V.S. Kalyanaraman, P. Luciw, and R. Sanchez-Pescador (1987) Molecular characvterization of human immunodeficiency virus from Zaire: nucleotide sequence analysis identifies conserved and variable domains of the envelope gene. Gene 52:71-82.

20. Barr, P.J., K.S. Steimer, E.A. Sabin, D. Parkes, C. George-Nascimento, J.C. Stephans, M.A. Powers, A. Gyenes, G.A. Van Nest, E.T. Miller, K.W. Higgins, and P.A. Luciw (1987) Antigenicity and immunogenicity of domains of the human immunodeficiency virus (HIV) envelope polypeptide expressed in the yeast Sacchromyces cerevisiae. Vaccine 5:90-101.

21. Barr, P.J., M.D. Power, C.Y. Lee-Ng, H.L. Gibson, and P.A. Luciw (1987) Expression of active human immunodeficiency virus reverse transcriptase in the yeast Saccharomyces cerevisiae. Biotechnology 5:486-489.

22. Luciw, P.A., C. Cheng-Mayer, and J.A. Levy (1987) Mutational analysis of the human immunodeficiency virus (HIV): the orf-B region down-regulates virus replication. Proc. Natl. Acad. Sci. USA 84:1434-1438.

23. Tong-Starksen, S., P.A. Luciw, and B.M. Peterlin (1987) Human immunodeficiency virus long terminal repeat responds to T-cell activation signals. Proc. Natl. Acad. Sci. USA 84:6845-6849.

24. Kao, S.Y., A.F. Calman, P.A. Luciw, and B.M. Peterlin (1987) HIV-1 transactivator (tat) regulates transcriptional elongation within the HIV-1 long terminal repeat. Nature. 330:489-493.

25. Jacks, T., M.D. Power, F.R. Masiarz, P.A. Luciw, P.J. Barr, and H.E. Varmus (1988) Characterization of ribosomal frameshifting in HIV-1 gag-pol expression. Nature 331:280-283.

26. Jones, K.A., P.A. Luciw, and N. Duchange (1988) Structural arrangements of transcription control elements within the 5'-untranslated leader regions of the HIV-1 and HIV-2 promoters. Genes and Development. 2:1101-1114.

27. Vogel, J., S.H. Hinrichs, R.K. Reynolds, P.A. Luciw, and G. Jay (1988) The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice. Nature. 335:606-611.

28. Srinivasan, A., C.S. Goldsmith, D. York, R. Anand, P. Luciw, G. Schochetman, E. Palmer, and C. Bohan (1988) Studies on human immunodeficiency virus-induced cytopathic effects: use of human rhabdomyosarcoma (RD) cells. Arch. Virol. 99:21-30.

29. Kalyanaraman, S., R. Jannoun-Nasr, D. York, P.A. Luciw, R. Robinson, and A. Srinivasan (1988) Homologous recombination between human immunodeficiency viral DNAs in cultured human cells: Analysis of the factors influencing recombination. Biochem. Biophys. Res. Comm. 157: 1051-1060.

30. Anand, R., R. Thayer, A. Srinivasan, M. Gardner, P. Luciw, and S. Dandekar (1989) Biological and molecular characterization of human immunodeficiency virus (HIV-1BR) from the brain of a patient with progressive dementia. Virology 168:79-89.

Peer-review publications (continued):

31. Tong-Starksen, S., P. A. Luciw, and B. M. Peterlin (1989) Signalling through T lymphocyte surface proteins, TCR/CD3 and CD28, activates the HIV-1 long terminal repeat. J. Immumol. 142:702-707.

32. Selby, M., E. Bain, P.A. Luciw, and B.M. Peterlin (1989) Structure, sequence, and postion of the stem-loop in tar determine transcriptional elongation by tat through the HIV-1 LTR. Genes and Development 3:547-558.

33. Talbott, R.L., E.E. Sparger, K.M. Lovelace, W.M. Fitch, N.C. Pedersen, P.A. Luciw, and J.H. Elder (1989) Nucleotide sequence and genomic organization of feline immunodeficiency virus (FIV). Proc. Natl. Acad. Sci. USA 86:5743-5747.

34. Srinivasan, A., D. York, R. Jannoun-Nasr, S. Kalyanaraman, D. Swan, J. Benson, C. Bohan, P.A. Luciw, S. Schnoll, R.A. Robinson, S.M. Desai, and S.G. Devare (1989) Generation of hybrid human immunodeficiency virus by homologous recombination. Proc. Natl. Acad. Sci. USA 86:6388-6392.

35. Bohan, C.A., R.A. Robinson, P.A. Luciw, and A. Srinivasan (1989) Mutational analysis of sodium butyrate inducible elements in the human immunodeficiency virus type 1 long terminal repeat. Virology 172: 573-583.

36. E.E. Sparger, P.A. Luciw, J.H. Elder, J.K. Yamamoto, L.J. Lowenstine, and N.C. Pedersen (1989) Feline immunodeficiency virus (FIV) is a lentivirus associated with an AIDS-like disease in cats (review). AIDS 3 (suppl 1):S43-S49.

37. Cheng-Mayer, C., P. Ianello, K. Shaw, P.A. Luciw, and J.A. Levy (1989) Differential effects of nef on replication: implications for viral pathogenesis in the host. Science 246:1629-1632.

38. Mergia, A., K.E.S. Shaw, J.E. Lackner, and P.A. Luciw (1990) Relationship of the env genes and the endonuclease domain of pol genes of simian foamy virus type 1 (SFV-1) and human foamy virus (HFV). J. Virol. 64:406-410.

39. Pedersen, N.C., M. Torten, B. Rideout, E. Sparger, T. Tonachini, P.A. Luciw, C. Ackley, N. Levy, and J. Yamamoto (1990) Feline immunodeficiency virus infection of cats and the role of feline leukemia virus infection as a disease potentiating cofactor. J. Virol. 64: 598-606.

40. Barry, P., E. Pratt-Lowe, B.M. Peterlin, and P.A. Luciw (1990) Cytomegalovirus activates transcription directed by the long terminal repeat of the human immunodeficiency virus type 1. J. Virol. 64:2932-2940.

41. Marthas, M.L., S. Sutjipto, J. Higgins, B. Lohman, J. Torten, P.A. Luciw, P.A. Marx, and N.C. Pedersen (1990) Immunization with a live, nonpathogenic simian immunodeficiency virus (SIV) prevents early disease but not infection in rhesus macaques challenged with pathogenic SIV. J. Virol. 64:3694-3700.

42. Mergia, A., K.E. Shaw, E. Pratt-Lowe, P.A. Barry, and P.A. Luciw (1990) Simian foamy virus type 1 (SFV-1) is a retrovirus which encodes a transcriptional transactivator. J. Virol. 64:3598-3604.

43. Carlson, J.R., T.P. McGraw, E. Keddie, J.L. Yee, A. Rosenthal, A.J. Langlois, R. Dickover, R. Donovan, P.A. Luciw, M.B. Jennings, and M.B. Gardner (1990) Vaccine protection of rhesus macaques against simian immunodeficiency virus infection. AIDS Res. Human Retroviruses. 6:1239-1246.

44. Barry, P.A., E. Pratt-Lowe, R.E. Unger, and P.A. Luciw (1991) Cellular factors regulate transactivation of the human immunodeficiency virus type 1. J. Virol. 64:1392-1399.

45. Unger, R.E., M.W. Stout, and P.A. Luciw (1991) Simian immunodeficiency virus (SIVmac) exhibits complex splicing for tat, rev, and env mRNA. Virology. 182:177-185.

46. Mergia, A., K.E.S. Shaw, E. Pratt-Lowe, M. Stout, and P.A. Luciw (1991) Identification of the transcriptional transactivator gene (taf) and target sequence encoded by simian foamy virus type 1. J. Virol. 65:2903-2909.

Peer-review publications (continued):

47. Banapour, B., M.L. Marthas, R. Munn, and P.A. Luciw (1991). In vitro macrophage tropism of pathogenic and nonpathogenic molecular clones of simian immunodeficiency virus (SIVmac). Virology. 18:12-19.

48. Planelles, V., N.L. Haigwood, M.L. Marthas, K.A. Mann, C. Scandella, W.D. Lidster, J.R. Shuster, R. Van Kuyk, P.A. Marx, M.B. Gardner, and P.A. Luciw (1991) Functional and immunological characterization of SIV envelope glycoprotein produced in genetically engineered mammalian cells. AIDS Res. and Human Retroviruses. 7:889-898.

49. Van Kuyk, R., R. Acevedo, R. Munn, R.E. Unger, N. Levy, M.B. Gardner, and P.A. Luciw (1991) Simian type-D retrovirus infection of B-cell lines from rhesus macaques. AIDS Res. and Human Retroviruses. 7:899-909.

50. Banapour, B., M.L. Marthas, R.A. Ramos, R.E. Unger, B. Lohman, M.B. Gardner, N.C. Pedersen, and P.A. Luciw (1991) Identification of viral determinants for macrophage tropism of simian immunodeficiency virus (SIVmac). J. Virol. 65:5798-5805.

51. Mergia, A., E. Pratt-Lowe, K.E.S. Shaw, L.W. Renshaw-Gegg, and P.A. Luciw (1992) Cis-acting regulatory regions in the long terminal repeat of (LTR) of simian foamy virus type 1 (SFV-1). J. Virol. 66:251-257.

52. Elder, J. H., D.L. Lerner, C.S. Hasselkus-Light, D.J. Fontenot, E. Hunter, P.A. Luciw, R.C. Montelaro, and T.R. Phillips (1992) Distinct subsets of retroviruses encode dexoyuridine triphosphatase. J. Virol. 66:1791-1794.

53. Sparger, E.E., B. Shacklett, L. Renshaw-Gegg, T. Phillips, J. Elder, N.C. Pedersen, and P.A. Luciw (1992) Regulation of feline immunodeficiency virus gene expression. Virology. 187:165-177.

54. Luciw, P.A., K.E.S. Shaw, R.E. Unger, V. Planelles, M.W. Stout, J.E. Lackner, E. Pratt-Lowe, N.J. Leung, B. Banapour, and M.L. Marthas (1992) Genetic and biologic comparisons of pathogenic and nonpathogenic molecular clones of simian immunodeficiency virus (SIVmac). AIDS Research and Human Retroviruses. 8: 395-402.

55. Unger, R., E., M.L. Marthas, E. Pratt-Lowe, P.A. Padrid, and P.A. Luciw (1992) The nef gene of simian immunodeficiency virus (SIVmac1A11). J. Virol. 66: 5432-5442.

56. Phillips, T.R., C. Lamont, D.A.M. Konings, B.L. Shacklett, P.A. Luciw, and J.H. Elder (1992) Identification of the REV transactivator and REV responsive element of feline immunodeficiency virus. J. Virol. 66: 5464-5471.

57. Giavedoni, L.D., V. Planelles, N.L. Haigwood, S. Ahmad, J.D. Kluge, M.L. Marthas, M.B. Gardner, P.A. Luciw, and T. Yilma (1993) Immune response of rhesus macaques to recombinant SIVgp130 does not protect from challenge infection. J. Virol. 67: 577-583.

58. Renne, R., A. Mergia, L. W. Renshaw-Gegg, D. Neumann-Haeflin, and P.A. Luciw (1993) Regulatory elements in the long terminal repeat (LTR) of simian foamy virus type 3 (SFV-3). Virology. 192: 365-369.

59. Alcendor, D.J., P.A. Barry, E. Pratt-Lowe, and P.A. Luciw (1993) Structure and function of the promoter of the rhesus cytomegalovirus immediate early gene. Virology. 194:815-821.

60. Marthas, M. L., R. Ramos, B. A. Lohman, K. Van Rompay, R. Unger, C. J. Miller, B. Banapour, and P.A. Luciw (1993) Viral determinants of simian immunodeficiency virus (SIV) virulence in rhesus macaques assessed using attenuated and pathogenic molecular clones of SIVmac. J. Virol. 67: 6047-6055.

61. Ahmad, S., Lohman, B., Marthas, M., Giavedoni, L., El-Ahmad, Z., Haigwood, N.L., Scandella, C.J., Gardner, M.B., Luciw, P.A., and Yilma, T. (1994) Reduced virus load in rhesus macaques immunized with recombinant gp160 and challenged with simian immunodeficiency virus. AIDS Res. and Human Retroviruses. 10: 195-204.

Peer-review publications (continued):

62. Herchenroeder, O., R. Renne, D. Loncar, K.E. Cobb, K.K. Murthy, A. Mergia, and P.A. Luciw (1994) Isolation, cloning, and sequencing of simian foamy viruses from chimpanzees (SFVcpz): high homology to human foamy virus (HFV). Virology. 201:187-199.

63. Campbell, M., L. Renshaw-Gegg, R. Renne, and P.A. Luciw (1994) Characterization of the internal promoter of simian foamy viruses. J. Virol. 68:4811-4820.

64. Shacklett, B.L. and P.A. Luciw (1994) Analysis of the vif gene of feline immunodeficiency virus (FIV). Virology 204:860-867.

65. Luciw, P. A., E. Pratt-Lowe, K. E. S. Shaw, J. A. Levy, and C. Cheng-Mayer (1995) Persistent infection of rhesus macaques with T-cell line-tropic and macrophage-tropic clones of simian/human immunodeficiency viruses (SHIV). Proc. Natl. Acad. Sci. USA 92: 7490-7494.

66. Allan, J.S., P. Ray, S. Broussard, E. Whitehead, G. Hubbard, T. Butler, K. Brasky, P. Luciw, C. Cheng-Mayer, J.A. Levy;, K. Steimer, J. Li, J. Sodroski, M. Garcia-Moll (1995) Infection of baboons with simian/human immunodeficiency viruses. Journal of AIDS 9:429-441.

67. Barry, P.A., D.J. Alcendor, M. Power, H. Kerr, and and P.A. Luciw (1996) Nucleotide sequence and molecular analysis of the rhesus cytomegalovirus immediate-early gene and the UL121-117 open reading frames. Virology 215:61-72.

68. Zou, J.X. and P.A. Luciw (1996) The transcriptional transactivator of simian foamy virus type 1 binds to a DNA target element in the viral internal promoter. Proc. Natl. Acad. Sci. USA 93: 326-330.

69. Zou, J.X. and P.A. Luciw (1996) The requirement for vif of SIVmac is cell-type dependent. J. Gen. Virol. 77: 427-434.

70. Himathongkham, S. and P.A. Luciw (1996) Restriction of HIV-1 replication at the entry step in rhesus macaque cells. Virology 219:485-488.

71. Renne, R., U. Fleps, P. A. Luciw, and D. Neumann-Haefelin (1996) Transactivation of the two promoters of SFV-3 by different mechanisms. Virology 221:362-367.

72. Campbell, M., C. Eng, and P. A. Luciw (1996) The simian foamy virus type-1 (SFV-1) transcriptional transactivator (Tas) binds and activates an enhancer element in the gag gene. J. Virol. 70: 6847-6855.

73. Sawai, E. T., I. H. Khan, P. M. Montbriand, C. J. Weber, C. Cheng-Mayer, and P. A. Luciw (1996) Activation of PAK by HIV and SIV Nef: Importance for AIDS in rhesus macaques. Current Biology 3: 1519-1527.

74. Chackerian, B., E.M. Long, P.A. Luciw, and J. Overbaugh (1997) Human immunodeficiency virus type 1 coreceptors participate in postentry stages in the virus replication cycle and function in simian immunodeficiency virus infection. J. Virol. 71:3932-3939.

75. Kravitz, R.H., K.S. Sciabica, K. Cho, P.A. Luciw, and P.A. Barry. (1997) Characterization of rhesus cytomegalovirus glycoprotein B. J. Gen. Virol. 78:2009-2013.

76. Tinkle, B.T., L. Ngo, P.A. Luciw, T. Maciag, G. Jay. Human immunodeficiency virus-associated vasculopathy in transgenic mice. J. Virol. 71:4809-4814.

77. Sparger, E.E., Ziomek, A., Louie, H., and Luciw, P.A. (1997) Infection of cats with DNA of a feline immunodeficiency virus molecular clone. Virology. 238:157-160.

78. Tarantal, A.F., S. Salamat, P.A. Luciw, A.G. Hendrickx, and P.A. Barry (1997) Rhesus monkey (Macaca mulatta) model for congenital cytomegalovirus disease. Submitted to J. Inf. Dis. In press.

79. Klinger, J., S. Himathongkham, H. Legg, P. A. Luciw, and S. Barnett (1997) Chimeric SHIV with HIV-1 subtype-E envelope gene is restricted at an early step for replication in macaque lymphocytes. AIDS. In press.

Submitted for publication:

  1. Harouse, J.M., R.C.H. Tan, A. Gettie, P. Dailey, P.A. Marx, P.A. Luciw, and C. Cheng-Mayer (1998) Primary viral infection after intra-vaginal inoculation with a pathogenic simian/human immunodeficiency virus, SHIV-33A. Submitted to J. Virol.
  2. Khan, I., E.T. Sawai, J. Weber, P. Montbriand, and P.A. Luciw (1998) Genetic analysis of functional domains of SIV Nef. Submitted to J. Virol.

Book editor:

1. Luciw, P.A. and K.S. Steimer, eds. (1989) HIV Detection by Genetic Engineering Methods (Marcel Dekker Inc., New York)

Monographs and reviews:

  1. Wu, G.J., P. A. Luciw, S. Mitra, G. Zubay, and H.S. Ginsberg (1977) Approaches to adenovirus transcription in vitro. In: Nucleic Acid - Protein Recognition. Ed. H.J. Vogel (Academic Press, New York).
  2. Gardner, M.B., N. Pedersen, P. Marx, R. Henrickson, P. Luciw, and R. Gilden (1984) Vaccination against virally induced tumors. In: Immunity to Cancer. Eds. Reif and Mitchell (Academic Press, New York).
  3. Luciw, P.A., D. Parkes, G. Van Nest, D. Dina, K. Hendrix, and M. Gardner (1985) Recombinant DNA approaches to FeLV immunization. In: Genetic Engineering of Animals - An Agricultural Persepective. Eds: J.W. Evans and A. Hollaender (Plenum Press, New York) pp. 207-215.
  4. Staben, C., J.M. Shimabukaro, J.C. Stephans, P.J. Barr, E.A. Sabin, D. Parkes, P.A. Luciw, K.S. Steimer, J.A. Levy, and D. Dina (1986) The nature and significance of sequence variation among independent AIDS retrovirus isolates. In: Modern Approaches to Viral Vaccines. Eds. R. Lerner, R. Chanock, and F. Brown (Cold Spring Harbor Laboratory).
  5. Steimer, K.S., G. Van Nest, D. Dina, P.J. Barr, P.A. Luciw, and E.T. Miller (1987) Genetically engineered human immunodeficiency virus envelope glycoprotein gp120 produced in yeast is the target of neutralizing antobodies. In: Vaccines '87. Eds. R. Chanock, F. Brown, R. Lerner, and H. Ginsberg (Cold Spring Harbor Laboratory) pp. 236-241.
  6. Srinivasan, A., B.M. Peterlin, P.J. Barr, M.D. Walker, R.F. Rando, P. Pellet, and P.A. Luciw (1987) Transactivations of gene expression directed by the long terminal repeat (LTR) of the human immunodeficiency virus (HIV). In: Vaccines '87. Eds. R. Chanock, F. Brown, R. Lerner, and H. Ginsberg (Cold Spring Harbor Laboratory) pp. 125-129.
  7. Gardner, M.B., P.A. Luciw, N. Lerche, and P.A. Marx (1988) Non-human primate retrovirus isolates and AIDS. In Immunodeficiency Disorders and Retroviruses. Advances in Vererinary Science and Comparative Medicine, vol. 32. Ed: K. Perk (Academic Press, New York). pp. 171-226.
  8. Luciw, P.A., S. Tong-Starksen, and B.M. Peterlin (1988) Expression directed by the long terminal repeat of the human immunodeficiency virus is enhanced in activated T-cells. UCLA Symposia on Molecular and Cellular Biology - Human Retroviruses, Cancer, and AIDS. 71:113-122.

Monographs and reviews (continued):

9. Peterlin, B.M., A.F. Calman, S.Y. Kao, M. Selby, S. Tong-Starksen, and P.A. Luciw (1988) Activation and trans-activation of human immunodeficiency virus type 1. In: The Control of Human Retrovirus Gene Expression. Eds: Franza, B.R., Cullen, B.R., and Wong-Staal, F. (Cold Spring Harbor Laboratory, New York). pp. 45-57.

10. Dinter, H., N. Duchange, K.A. Jones and P.A. Luciw (1988) Complex arrangement of cellular transcription factor binding domains and regulatory signals within the HIV-1 promoter. In: The Control of Human Retrovirus Gene Expression. Eds: Franza, B.R., Cullen, B.R., and Wong-Staal, F. (Cold Spring Harbor Laboratory, New York). pp. 227-238.

11. Peterlin, B.M., A.F. Calman, S.Y. Kao, M.J. Selby, S.E. Tong-Starksen, and P.A. Luciw (1988) Transcriptional regulation of human immunodeficiency virus - 1. Vaccines 88. Eds. F. Brown, R. Chanock, H. Ginsberg, and R. Lerner (Cold Spring Harbor Laboratory, NY). pp. 283-290.

12. Peterlin, B.M. and P.A. Luciw (1988) Molecular Biology of HIV (review). AIDS. 2 (Suppl. 1): 29-40.

13. Gardner, M. B. and P. A. Luciw (1988) Simian immunodeficiency viruses and their relationship to the human immunodeficiency viruses (review). AIDS. 2 (Suppl. 1): 3-10.

14. Peterlin, B. M. and P. A. Luciw (1988) Replication of the human immunodeficiency virus: strategies for inhibition (review). Biotechnology 6:794-799.

15. Gardner, M.B., M. Jennings, J.R. Carlson, N. Lerche, T. McGraw, P. Luciw, P. Marx, and N. Pedersen (1989) Post-exposure immunotherapy of SIV infected rhesus with an SIV immunogen. J. Med. Primatol. 18: 321-328.

16. Marthas, M., B. Banapour, S. Sutjipto, M.E. Siegel, P.A. Marx, M.B. Gardner, N.C. Pedersen, and P.A. Luciw (1989) Rhesus macaques inoculated with molecularly cloned simian immunodeficiency virus. J. Med. Primatol. 18: 311-319.

17. Gardner, M., P.A. Luciw, P. Marx, N. Lerche, T. McGraw, M. Jennings, J. Carlson, and N. Pedersen (1989) An approach to immunotherapy of simian immunodeficiency virus-infected rhesus with an inactivated whole SIV immunogen. In: Vaccines '89. Eds. F. Brown, R. Chanock, H. Ginsberg, and R. Lerner (Cold Spring Harbor Laboratory, New York).

18. Gardner, M.B. and P.A. Luciw (1989) Animal models of AIDS (review). FASEB J. 3:2593-2606.

19. Sparger, E.E., P.A. Luciw, J.H. Elder, J.K. Yamamoto, L.J. Lowenstine, and N.C. Pedersen (1989) Feline immunodeficiency virus (FIV) is a lentivirus associated with an AIDS-like disease in cats (review). AIDS 3 (supplement): 43-49.

20. Torten, M., B. Rideout, E.E. Sparger, P.A. Luciw and N.C. Pedersen (1990) Coinfection of cats with FIV and FeLV effects both quantity and distribution of FIV DNA in various tissues. In: Vaccines '90. Eds. F. Brown, R. Chanock, H. Ginsberg, and R. Lerner (Cold Spring Harbor Laboratory, NY). pp. 375-378.

21. McGraw, T.P., B.R. Vowels, J.R. Carlson, P. A. Luciw, T. Yilma, P. Marx, N. Haigwood, K.S. Steimer, and M.B. Gardner (1990) Immune response of nonhuman primates infected with SIV and immunogenicity studies of lentivirus vaccine products. In: Vaccines '90. Eds. F. Brown, R. Chanock, H. Ginsberg, and R. Lerner (Cold Spring Harbor Laboratory, NY). pp 389-392.

22. Barry, P.A., E. Pratt-Lowe, R.E. Unger, M. Marthas, D.J. Alcendor, and P.A. Luciw (1990) Molecular interactions of cytomegalovirus and the human and simian immunodeficiency viruses. J. Med. Primatol. 19:327-337.

23. Barry, P.A., E. Pratt-Lowe, D.J. Alcendor, E. Unger, and P.A. Luciw (1990) Molecular interactions between human immunodeficiency virus type 1 and human cytomegalovirus. Ann. New York Acad. Sci. 616:54-63.

Monographs and reviews (continued):

24. Torten, M., B.A. Rideout, P.A. Luciw, E.E. Sparger, and N.C. Pedersen (1990) Co-infection of cats with feline immunodeficiency virus (FIV) and feline leukemia virus (FIV) enhances the severity of FIV infection and affects the distribution of FIV DNA in various tissues. In: Animal Models in AIDS. Eds. H. Schellekens and M.C. Horzinek (Elsevier, Amsterdam). pp 209-219.

25. Fiala, M., J.D. Mosca, P. Barry, P.A. Luciw, and H.V. Vinters (1991) Multi-step pathogenesis of AIDS - role of cytomegalovirus. Res. Immunol. 142: 87-95.

26. Mergia, A. and P.A. Luciw (1991) Replication and regulation of primate foamy viruses (minireview). Virology. 184:475-482.

27. Gardner, M.B. and P.A. Luciw (1992) Simian Retroviruses. In AIDS and Other Manifestations of HIV Infection, 2nd edition. Ed: G.P. Wormser (Raven Press, New York). 127-144.

28. Luciw, P.A. and N.J. Leung (1992) Mechanisms of retrovirus replication. Retroviridae, Vol. 1. Eds: J.A. Levy and H. Frankel-Conrat (Plenum Press, NY). 159-298.

29. Unger, R.E., M.L. Marthas, A.A. Lackner, E. Pratt-Lowe, B.L. Loman, K.V. Rompay, and P.A. Luciw (1992) Detection of simian immunodeficiency virus DNA in macrophages from infected rhesus macaques. J. Med. Primatol. 20:74-81.

30. Gardner, M., J. Yamamoto, M. Marthas, C. Miller, M. Jennings, A. Rosenthal, P. Luciw, V. Planelles, T. Yilma, L. Giavedoni, S. Ahmed, K. Steimer, N. Haigwood, and N. Pedersen (1992) SIV and FIV vaccine studies at UC Davis: 1991 update. AIDS Res. and Human Retroviruses 8:11495-1498.

31. Planelles, V., P.A. Luciw, M.B. Gardner, L. Giavedoni, S. Ahmad, T. Yilma, M. Marthas, P. Marx, A. Lackner, C.J. Scandella, N.L. Haigwood. (1992) Vaccine studies with SIVmac1A11 recombinant gp130: lack of protection from SIVmac251 challenge. In: Vaccines '92. Eds: F. Brown, R. Chanock, H. Ginsberg, and R. Lerner (Cold Spring Harbor Laboratory, NY). pp. 123-129.

32. Ahmad, S., El-Amad, Z, Giavedoni, L., Marthas, M., Haigwood, N.L., Kilpatrick, J., Scandella, C.J., Gardner, M.B., Luciw, P.A., and Yilma, T. (1993) Immune responses of rhesus macaques to recombinant SIV gp160 does not protect from challenge infection. In: Vaccines '93. Eds: F. Brown, R. Chanock, H. Ginsberg, and R. Lerner (Cold Spring Harbor Laboratory, NY). pp. 57-62.

33. Luciw, P. A., A. Mergia, and P. C. Loh (1992) Spumaviruses. Encyclopedia of Virology. Ed: R. G. Webster and A. Granoff (Saunders Scientific, London). 480-488.

34. Luciw, P.A. and B.L. Shacklett (1993) Molecular biology of the human and simian immunodeficiency viruses. In: HIV Molecular Organization, Pathogenicity and Treatment. Eds: J. Morrow and N. Haigwood (Elsevier Science Publishers, Amsterdam). pp. 123-219.

35. McChesney, M.B., B.L. Lohman, K.A. Van Rompay, E. McGowan, S. Joye, P.A. Luciw, N.C. Pedersen, C.J. Miller, and M.L. Marthas (1993) SIV gp120 recombinant viruses are attenuated and immunogenic. In: Vaccines '94. Eds: F. Brown, R. Chanock, H. Ginsberg, and E. Norrby (Cold Spring Harbor Laboratory, NY). 225-229.

36. Luciw, P.A. (1996) Human immunodeficiency viruses and their replication. In: Fields Virology. Eds: B. Fields et al. (Raven Press, NY). 1881-1952.

37. Sawai, E.T., C. Cheng-Mayer, and P.A. Luciw. 1996. Nef and the Nef-associated kinase. Research in Virology. 148:47-52.

38. Gardner, M.B. and P.A. Luciw (1997) Simian Retroviruses. In AIDS and Other Manifestations of HIV Infection, 3rd edition. Ed: G.P. Wormser (Raven Press, New York). 217-256.

39. Overbaugh, J., P.A. Luciw, and E.A. Hoover. 1997. Models for AIDS pathogenesis: SIV, SHIV, and FIV infections. AIDS. 11:S47-S54.

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