T. Alber, Q. Zhou & E. Nogales, instructors
Selections from Alberts et al., Molecular Cell Biology of the Cell, 4th Edition (2002):PDFs of Alberts Chapters 1, 5, 17, and 23 at www.garlandscience.com.
Alberts Chapter 1 (PDF)
Alberts Chapter 4 (PDF)
Alberts Chapter 5 (PDF)
Alberts Chapter 6 (PDF)
Alberts Chapter 7 (PDF)
Alberts Chapter 8 (PDF)
Alberts Chapter 10 (PDF)Online Chapter selections can be found through NCBI Bookshelf
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NUCLEIC ACID STRUCTURE AND DNA METABOLISM
| Lecture | Date | Lecturer | Topic |
|---|---|---|---|
| Nucleic Acid structure | |||
| 1-1 | M Aug 27 | Thorner | Not your grandfather’s DNA: Variations in DNA structure Alberts: [Ch. 1] 3-6 [Ch. 4] 191-197, [Ch. 8] 513-517 495-500 |
| 1-2 | W Aug 29 | Thorner | (Twisted) Principles of RNA structure and recognition Alberts: [Ch. 1] 6-10 [Ch.6] 302-304, 337-339 346-348 368-370 |
| DNA Replication | |||
| 1-3 | F Aug 31 | Berger | DNA polymerases: poor enzymes doing half the job Alberts: [Ch. 4] 235-243 |
| 1-4 | W Sept 5 | TA | The DNA replication fork: collaborate or die Alberts: [Ch. 5] 244-255 |
| 1-5 | F Sept 7 | TA | Other replication factors: it takes a village Alberts: [Ch. 5] 248-255 |
| 1-6 | M Sept 10 | TA | Replication origins and ends: regulation Alberts: [Ch. 5] 255-266 Lodish: 1143-47 |
| Genome structure and analysis | |||
| 1-7 | W Sept 12 | TA | You say you want a revolution: DNA analysis methods Alberts: [Ch.8] 491-513, 518, 524, 536-545 |
| 1-8 | F Sept 14 | TA | DNA analysis methods II Lodish: 176-198, 204-210 |
| 1-9 | M Sept 17 | TA | DNA wrap: Chromatin and chromosome structure Lodish: 247-66 (Optional: Alberts Ch. 4, 198-234) |
| 1-10 | W Sept 19 | TA | Genome structures: what’s in a model (organism) Alberts: [Ch. 1] 13-28 Lodish: 215-242 |
| 1-11 | F Sept 21 | TA | Genomics and Bioinformatics: Time machines and function Lodish: 243-247 |
| DNA Repair and Disease Genes | |||
| 1-12 | M Sept 24 | TA | Human disease genes: risky science and the new “infinity” Lodish: 198-204 |
| 1-13 | W Sept 26 | TA | DNA damage and repair: oops, ouch! Alberts: [Ch. 5] 267-275, [Ch. 23] 1352-1355 (Optional: Lodish 145-154 (eukaryotes)) |
| 1-14 | F Sept 28 | TA | Recombination and repair in cancer Alberts: [Ch. 5] 275-285 Lodish: Chapter 25, especially 1107-08, 1119-27, 1138-47 |
| Exam | Oct | 2 | EXAM #1 6:30 - 8:30 pm (Tuesday) Evans 10 & 60 |
REGULATION OF GENE EXPRESSION
Readings are from “Molecular Cell Biology” 6th edition by Lodish et al. Readings are intended to provide a second source of explanation for material that you may not understand in class. You are responsible ONLY for text material that is directly related to the lectures. Reading the text will not substitute for coming to class.
| 2-1 | M Oct 1 | QZ | Prokaryotic Transcription Apparatus: Part I Text: Ch. 4, p. 120-123; Ch. 7, p. 271-275 |
| 2-2 | W Oct 3 | QZ | Prokaryotic Transcription Apparatus: Part II Text: Ch. 4, p. 120-123; Ch. 7, p. 271-275 |
| 2-3 | F Oct 5 | QZ | Control of Prokaryotic Transcription: Part I Text: Ch. 4, p. 120-123; Ch. 7, p. 271-275 |
| 2-4 | M Oct 8 | QZ | Control of Prokaryotic Transcription: Part II Text: Ch. 4, p. 120-123; Ch. 7, p. 271-275 |
| 2-5 | W Oct 10 | QZ | Eukaryotic Transcription Apparatus & Methods to Analyze Transcription: Part I Text: Ch. 7, p. 276-298 |
| 2-6 | F Oct 12 | QZ | Eukaryotic Transcription Apparatus & Methods to Analyze Transcription: Part II Text: Ch. 7, p. 276-298 |
| 2-7 | M Oct 15 | QZ | Eukaryotic Transcription Apparatus & Methods to Analyze Transcription: Part III Text: Ch. 7, p. 276-298 |
| 2-8 | W Oct 17 | QZ | Control of Eukaryotic Transcription: Part I Text: Ch. 7, p. 299- 316 |
| 2-9 | F Oct 19 | QZ | Control of Eukaryotic Transcription: Part II Text: Ch. 7, p. 299- 316 |
| 2-10 | M Oct 22 | QZ | Control of Eukaryotic Transcription: Part III Text: Ch. 7, p. 299- 316 |
| 2-11 | W Oct 24 | QZ | RNA Processing: Part I Text: Ch. 8, p. 323-340; 363-364 |
| 2-12 | F Oct 26 | QZ | RNA Processing: Part II Text: Ch. 8, p. 323-340; 363-364 |
| 2-13 | M Oct 29 | QZ | Control of Translation: Part I Text: Ch. 4, p. 127-139 |
| 2-14 | W Oct 31 | QZ | Control of Translation: Part II Text: Ch. 4, p. 127-139 |
| Exam | Nov | 5 | EXAM #2 6:30 - 8:30 pm (Monday) 100 GPBB |
BIOCHEMICAL CELL BIOLOGY
1 MEMBRANE LIPIDS AND LIPID BILAYERI Intro to Biological Membranes2 MEMBRANE PROTEINS
II Membrane Lipids
III Lipid Self-Assembly
IV Membrane FluidityI Introduction to Membrane Proteins3 TRANSPORT ACROSS MEMBRANES
II Integral Membrane Proteins
III Peripheral Membrane Proteins
IV Lipid-Anchored Membrane Proteins
V Diffusion of Membrane ProteinsI Intro: Permeability of the Cell Membranes4 MEMBRANE TRAFFICKING
II Diffusion
III Facilitated Diffusion
IV Active Transport
V Membrane Potential and Nerve ImpulsesI Introduction: Secretory Pathway5 CELL SIGNALING
II Endoplasmic Reticulum
III Golgi
IV Vesicle Transport
V Lisosomes
VI EndocytosisI Introduction
II G Protein-coupled Receptors
III Receptor Tyrosine Kinases
IV Integrin Signaling
V Cell Signaling and Apoptosis
VI Relationships between
| Dec | 13 | FINAL Thursday, 8:00 - 11:00 AM, Location TBA |